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Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease.
Front Endocrinol (Lausanne)
January 2025
Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, Liaoning, China.
Objective: The impact of lipid-lowering medications on chronic kidney disease (CKD) remains a subject of debate. This Mendelian randomization (MR) study aims to elucidate the potential effects of lipid-lowering drug targets on CKD development.
Methods: We extracted 11 genetic variants encoding targets of lipid-lowering drugs from published genome-wide association study (GWAS) summary statistics, encompassing LDLR, HMGCR, PCSK9, NPC1L1, APOB, ABCG5/ABCG8, LPL, APOC3, ANGPTL3, and PPARA.
Interplay between conformational dynamics and substrate binding regulates enzymatic activity: a single-molecule FRET study.
Chem Sci
January 2025
Department of Chemical and Biological Physics, Weizmann Institute of Science Rehovot 761001 Israel
Proteins often harness extensive motions of domains and subunits to promote their function. Deciphering how these movements impact activity is key for understanding life's molecular machinery. The enzyme adenylate kinase is an intriguing example for this relationship; it ensures efficient catalysis by large-scale domain motions that lead to the enclosure of the bound substrates ATP and AMP.
View Article and Find Full Text PDFEffects of feeding different proportions of steam-flaked corn-based starter on growth performance, immunity and serum metabolism of pre-weaned Simmental calves.
Front Vet Sci
January 2025
College of Animal Science, Xinjiang Agricultural University, Urumqi, China.
Introduction: This study examines the effects of steam-flaked corn starter on pre-weaned Simmental calves' growth, immunity, and metabolism. Despite benefits shown in adult cattle, research on calves is limited. The goal is to optimize calf feeding for better growth, health, and nutrient use.
View Article and Find Full Text PDFDeep eutectic solvent-assisted carbon quantum dots from biomass : A fluorescent sensor for nanomolar detection of dual analytes mercury (Ⅱ) and glutathione.
Heliyon
January 2025
Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, 147004, India.
Deep eutectic solvents (DESs) have attracted significant attention in recent years due to its environment friendly characteristics and its participation in the multi-heteroatom doping of carbon quantum dots (CQDs). In this work, we present a simple, fast, and environment-friendly microwave synthesis approach for the synthesis of DES-assisted nitrogen and chloride co-doped CQDs (N,Cl-CQDs) using a choline chloride-urea based DES. A biomass-based precursor, i.
View Article and Find Full Text PDFNetwork pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease.
Front Immunol
January 2025
Department of Geriatrics, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Objective: Chronic kidney disease (CKD) is a major global health problem. In clinical practice, the Chinese patent herbal medicine Jianpi-Yishen (JPYS) formula is commonly used to treat CKD. However, the molecular mechanisms by which JPYS targets and modulates the host immune response remain unclear.
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