Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Tedizolid for osteoarticular infections: evaluation of the published evidence.
Eur J Pharmacol
March 2025
Alfa Institute of Biomedical Sciences, Athens, Greece; European University Cyprus School of Medicine, Nicosia, Cyprus; Tufts University School of Medicine, Boston, Massachusetts, USA. Electronic address:
Introduction: Tedizolid phosphate, an oxazolidinone antibiotic, has been approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). However, its off-label use has been reported in various infections, including osteoarticular infections.
Methods: A systematic review of data from PubMed, Scopus, and Web of Science was conducted to evaluate the antimicrobial activity, safety, and effectiveness of tedizolid in patients with bone and joint infections, including prosthetic joint infections, osteomyelitis, and septic arthritis.
The contribution of metagenomic next-generation sequencing to a diagnosis of gas-producing Fusobacterium-induced septic hip arthritis: A case report.
J Infect Chemother
March 2025
Department of Infectious Diseases and Laboratory Medicine, Kanazawa University, Kanazawa 920-8641, Japan.
Pyogenic arthritis with gas gangrene triggered by intra-articular steroid injections can occasionally result in fatal complications. Clostridium perfringens is typically the causative pathogen, with infections caused by Fusobacterium sp. being relatively rare.
View Article and Find Full Text PDFTopical Steroid Withdrawal Is a Targetable Excess of Mitochondrial NAD.
J Invest Dermatol
February 2025
Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:
Topical steroid withdrawal (TSW) is a controversial diagnosis advocated by patients but often confused for atopic dermatitis. We conducted a multimodal pilot study of 16 patients fitting the TSW diagnostic profile, contrasting them against patients with atopic dermatitis (n = 10) and healthy controls (n = 11). Our clinical evaluations established objective diagnostic criteria that distinguish TSW from atopic dermatitis, metabolomics and transcriptomics of skin biopsies suggested that neuroinflammatory pathways are associated with complex I-mediated oxidation of NAD+, cellular and mouse models demonstrated that NAD+ metabolism was proinflammatory and glucocorticoid responsive, whereas functional assays demonstrated that the metabolic effects of glucocorticoids on the only cell type that aligns with the distribution and duration of TSW pathology could be mitigated by complex I blockade.
View Article and Find Full Text PDFSlipped Capital Femoral Epiphysis in a 26-Month-Old Boy with Cerebral Palsy: A Case Report.
JBJS Case Connect
January 2025
Department of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Case: A 26-month-old child with spastic quadriplegic cerebral palsy, TPN dependence, laryngomalacia, and G6PD deficiency presented with right hip pain with no known recent trauma. Imaging revealed a slipped capital femoral epiphysis (SCFE). The patient underwent hip irrigation and debridement for potential septic arthritis, with SCFE stabilized using buried 2.
View Article and Find Full Text PDFSecukinumab in refractory non-infectious anterior uveitis.
Front Ophthalmol (Lausanne)
February 2025
Ophthalmology Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
Background: Secukinumab is a monoclonal antibody that selectively neutralizes interleukin-17A and has shown efficacy in the treatment of psoriatic arthritis, psoriasis, and axial spondyloarthritis. Its use in non-anterior non-infectious uveitis is controversial, with evidence generally not supporting its effectiveness in these conditions. However, the role of secukinumab in anterior non-infectious uveitis remains unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!