Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Structural and Functional Insights into UDP-N-acetylglucosamine-enolpyruvate Reductase (MurB) from Brucella ovis.
Arch Biochem Biophys
January 2025
Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain; Instituto de Biocomputación y Física de Sistemas Complejos (BIFI) Universidad de Zaragoza, and GBsC (Unizar) join unit to CSIC, Zaragoza, Spain. Electronic address:
The peptidoglycan biosynthetic pathway involves a series of enzymatic reactions in which UDP-N-acetylglucosamine-enolpyruvate reductase (MurB) plays a crucial role in catalyzing the conversion of UDP-N-acetylglucosamine-enolpyruvate (UNAGEP) to UDP-N-acetylmuramic acid. This reaction relies on NADPH and FAD and, since MurB is not found in eukaryotes, it is an attractive target for the development of antimicrobials. MurB from Brucella ovis, the causative agent of brucellosis in sheep, is characterized here.
View Article and Find Full Text PDFHuman and animal brucellosis and risk factors for human infection in Ethiopia: a systematic review and meta-analysis (2015-2024).
BMC Public Health
December 2024
Department of Veterinary Epidemiology and Public Health, College of Veterinary Medicine and Animal Science, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
Background And Objective: Brucellosis is a neglected zoonotic disease caused by Brucella species. Unlike most developed nations, the problem of brucellosis in Ethiopia remains a public and animal health concern. This study was conducted to determine the magnitude of brucellosis in animals (mainly cattle, sheep, goats, dogs and camels) and humans, and to identify the risk factors for human brucellosis.
View Article and Find Full Text PDFEffectiveness of the RB51 vaccine in controlling brucellosis in adult beef cows.
Front Vet Sci
November 2024
MSD Animal Health, São Paulo, São Paulo, Brazil.
Introduction: The aim of this study was to compare the effectiveness of brucellosis control and reproductive performance using one or two doses of RB51 strain vaccine.
Methods: This experiment was conducted at two commercial beef farms (A, = 477; and B, = 673), which were selected due to their records of endemic brucellosis and a prevalence of 6 to 8% of seropositive cows. An initial serology screening (Day 0) was carried out in all cows using the Rose Bengal test (RB), and presumptive positive results were re-evaluated using a slow agglutination test with 2-mercaptoethanol (2-ME).
Closely Related Brucella Species Widely Differ in their Vegetative and Intracellular Growth.
Curr Microbiol
November 2024
Laboratorio de Genómica Experimental Bacteriana, Instituto de Investigaciones Biotecnológicas, Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Campus Miguelete, Av. 25 de mayo y Francia CP (1650), San Martín, Buenos Aires, Argentina.
Growth rate is a key prokaryotic trait that allows for estimating fitness and understanding cell metabolism. While it has been well studied in model organisms, there is limited data on slow-growing bacteria. In particular, there is a lack of quantitative studies on Brucella species.
View Article and Find Full Text PDFBrucella microti and Rodent-Borne Brucellosis: A Neglected Public Health Threat.
Zoonoses Public Health
February 2025
Department 1 - Infectious Diseases, Robert Koch Institute, Berlin, Germany.
Brucellosis is one of the most important zoonoses worldwide, primarily affecting livestock but also posing a serious threat to public health. The major Brucella species are known to cause a feverish disease in humans with various clinical signs. These classical Brucella species are (re-)emerging, but also novel strains and species, some of them transmitted from rodents, can be associated with human infections.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!