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Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner.
Exp Neurol
January 2025
Laboratory of Neurodegenerative Diseases and Neuroinjury Diseases, Wuxi, School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China; MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:
Abnormal tryptophan metabolism is closely linked with neurological disorders. Research has shown that indoleamine 2,3-dioxygenase 1 (IDO-1), the first rate-limiting enzyme in tryptophan degradation, is upregulated in Parkinson's disease (PD). However, the precise role of IDO-1 in PD pathogenesis remains elusive.
View Article and Find Full Text PDFFecal microbiota transplantation from postmenopausal osteoporosis human donors accelerated bone mass loss in mice.
Front Cell Infect Microbiol
December 2024
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objectives: To investigate the effect of gut microbiota from postmenopausal osteoporosis patients on bone mass in mice.
Methods: Fecal samples were collected from postmenopausal women with normal bone mass (Con, n=5) and postmenopausal women with osteoporosis (Op, n=5). Microbial composition was identified by shallow shotgun sequencing.
Sorption behavior of oxytetracycline on microplastics and the influence of environmental factors in groundwater: Experimental investigation and molecular dynamics simulation.
J Contam Hydrol
December 2024
School of Water and Environment, Chang'an University, Xi'an 710054, China; Key Laboratory of Subsurface Hydrology and Ecology in Arid Areas, Ministry of Education, Chang'an University, Xi'an 710054, China; Key Laboratory of Eco-hydrology and Water Security in Arid and Semi-arid Regions of Ministry of Water Resources, Chang'an University, Xi'an 710054, China. Electronic address:
Microplastics (MPs) and antibiotics can enter groundwater through the interaction of soil and surface water, and MPs as carriers of antibiotics can promote the migration of antibiotics and thus generate more serious ecological risks. Therefore, this paper used experimental and molecular dynamics (MD) simulation methods to investigate the sorption between four common types of MPs in groundwater, namely polyamide (PA), polystyrene (PS), polyvinyl chloride (PVC), and polyethylene (PE), and oxytetracycline (OTC) with high detection rate in groundwater. Additionally, the impact of environmental factors on sorption was examined.
View Article and Find Full Text PDFThiol-Functionalized Cobalt Ferrite (CoFeO@MPTS) Nanoparticles as Cutting-Edge Adsorbents for Bovine Serum Albumin.
J Fluoresc
December 2024
National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.
This paper describes the synthesis of CoFe₂O₄ nanoparticles via a simple ultrasonic-assisted co-precipitation method and their functionalization with thiol groups using (3-Mercaptopropyl)trimethoxysilane (MPTS) as the functionalizing agent. The use of ultrasonic energy not only serves as a green energy source but also reduces the reaction time fivefold compared to conventional methods. The synthesized CoFe₂O₄ nanoparticles were characterized for their surface and internal properties using instrumental techniques such as Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Vibrating Sample Magnetometer (VSM).
View Article and Find Full Text PDFIntroduction: Chimeric antigen receptor T-cell (CAR-T) therapy is highly effective in B-cell blood cancers, but there is limited data on its safety and efficacy in intra-cardiac lymphoma, due to the potential risks of cardiotoxicity and pseudo-progression.
Discussion: We discuss four high-risk cases that were managed with a multi-disciplinary approach, including baseline cardiac risk assessment and surveillance with multimodal cardiac imaging and serum cardiac biomarkers, elective supportive care in the intensive care unit, and early treatment of cytokine release syndrome.
Conclusion: CAR-T therapy can be effective and safe in the treatment of B-cell blood cancers with intra-cardiac disease.
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