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Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease.
Noncoding RNA Res
April 2025
Department of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
MicroRNAs (miRNAs) are classified as small, non-coding RNAs that play crucial roles in diverse biological processes, including cellular development, differentiation, growth, and metabolism. MiRNAs regulate gene expression by recognizing complementary sequences within messenger RNA (mRNA) molecules. Recent studies have revealed that miR-145-5p functions as a tumor suppressor in several cancers, including lung, liver, and breast cancers.
View Article and Find Full Text PDFLook above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction.
Therap Adv Gastroenterol
December 2024
Division of Gastroenterology & Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Perelman Center for Advanced Medicine, 750 South 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Background: Esophagogastric junction outflow obstruction (EGJOO) is a manometric diagnosis based on Chicago Classification version 4.0 (CC4.0) that requires confirmatory testing for clinical relevancy.
View Article and Find Full Text PDFInnovative use of a 3-Fr microcatheter for precision guidewire placement with digital single-operator cholangioscopy for pancreaticobiliary drainage (with video).
Sci Rep
December 2024
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku Nagoya, Nagoya, Aichi, 467-8601, Japan.
Biliary and pancreatic tract stenosis are hallmark symptoms in pancreaticobiliary diseases, transcending malignancy. Endoscopic techniques are pivotal for biliary/pancreatic drainage; however, challenging scenarios arise when attempting to pass a guidewire (GW) through obstruction. Cholangioscopy-assisted GW placement has proven valuable, but challenges persist in its execution, particularly in maneuvering the GW through cholangioscopy.
View Article and Find Full Text PDFA Case Report of Rapunzel Syndrome in 14-Year-Old Girl.
Cureus
November 2024
Department of General and Operative Surgery, Medical University "Prof. Dr. Paraskev Stoyanov", Varna, BGR.
Trichobezoar or hairball in the proximal part of the gastrointestinal tract is a rare condition that occurs mainly in young and adolescent females. Since human hair is resistant to digestive enzymes and resistant to peristalsis, it easily accumulates between the folds of the mucosa. Over time, food and mucus accumulate within the hair, forming a compact mass that fills almost the entire lumen.
View Article and Find Full Text PDFOgilvie's Syndrome Following Herpes Zoster Infection: A Comprehensive Review of the Literature.
Cureus
November 2024
Department of General Surgery, Western General Hospital, Edinburgh, GBR.
This systematic review explores the association between herpes zoster (HZ) infection and Ogilvie's syndrome (acute colonic pseudo-obstruction), evaluating how varicella-zoster virus (VZV) reactivation may contribute to autonomic dysfunction leading to intestinal obstruction. A comprehensive search was conducted in PubMed, Scopus, and Cochrane Library databases up to October 2024, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies included case reports, clinical images, and letters reporting Ogilvie's syndrome secondary to HZ or VZV infection.
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