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Neurofibromatosis type 1 (NF1), which is also known as von Recklinghausen's disease, is a multisystem genetic disease that is principally associated with cutaneous, neurologic and orthopedic manifestations. The present case report described an unusual case with a giant cutaneous neoplasm on the right breast skin of a 36-year-old female who was admitted to the Department of Breast Surgery at the Affiliated Tumor Hospital of Xinjiang Medical University (Urumqi, China). Skin mass excision was performed and histopathology confirmed the diagnosis of thoracic plexiform neurofibroma as a primary presentation of NF1.

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  • * A 68-year-old man with NF1 had multiple small intestinal GISTs causing anemia and underwent surgery to remove them; two years later, he developed an enlarging mass in the appendix that was surgically removed due to concerns about its potential malignancy.
  • * Post-surgery, the diagnosis of an appendiceal neurofibroma was confirmed, highlighting the challenge in identifying these lesions preoperatively and stressing the importance of surgical
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On the misuse of evolutionary theory to bolster the 'scientific' case for intelligent design: A cautionary note.

J Theor Biol

January 2025

Westfälische Hochschule Gelsenkirchen / Bocholt / Recklinghausen, Campus Recklinghausen, Dept. of Molecular Biology, Faculty of Engineering and Natural Sciences, August-Schmidt-Ring 10, D-45665 Recklinghausen, Germany. Electronic address:

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Background: The COVID-19 pandemic has profoundly impacted the field of surgery, mostly through infectious risks, staff shortages, reduced hospital capacities, and changed patient pathways. Prompted by an increase in wound complications, we performed an in-depth analysis of an example surgical procedure.

Methods: A consecutive cohort of 195 patients undergoing laparoscopic cholecystectomy was studied retrospectively.

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  • - Neurofibromatosis type 1 (NF1) is a common genetic disorder that primarily causes neurofibromas and various vascular issues, such as aneurysms and arterial stenosis.
  • - A 45-year-old male with NF1 experienced a rare tension hemothorax caused by bleeding from the left costocervical artery, which is typically linked to trauma or aortic aneurysms.
  • - The patient was successfully treated with chest drainage and transcatheter arterial embolization (TAE) to manage the bleeding, highlighting the need for clinicians to consider potential non-traumatic complications in NF1 patients.
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