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α-adrenoblockers modulatory effect on the noise-mediated several biochemical and morpho-immuno-histochemical changes in the rat's blood plasma and tissues.
Immunol Res
January 2025
Department of Medical Chemistry, Yerevan State Medical University After M. Heratsi, Koryun Str., 0025, Yerevan, Armenia.
Experimental studies of chronic noise exposure in modern urban life testified about oxidative stress due to the corresponding hormones effects leading to accumulation of reactive oxygen species and endothelial dysfunction. This study aims to evaluate the protective effect of α2-adrenoblockers to modulate oxidative stress and corticosterone levels due to chronic noise exposure. To achieve this, we examined the effects of beditin (2-aminothiozolyl-1,4-benzodioxane) and mesedin (2-(2-methyl-amino-thiozolyl)-1,4-benzodioxane hydrochloride), along with changes in corticosterone, Ca2 + content, and morphological alterations in various tissues under noise-induced stress.
View Article and Find Full Text PDFTissue remodeling during high-altitude pulmonary edema in rats: Biochemical and histomorphological analysis.
Tissue Cell
January 2025
Department of Human and Animal Physiology, Yerevan State University, Yerevan, 1 Alek Manukyan St, Yerevan 0025, Armenia; Research Institute of Biology, Yerevan State University, Yerevan, 1 Alek Manukyan St, Yerevan 0025, Armenia. Electronic address:
High altitude characterized by the low partial pressure of the oxygen is a life-threatening condition that contributes to the development of acute pulmonary edema and hypoxic lung injury. In this study, we aimed to investigate the contribution of some inflammatory and oxidative stress markers along with antioxidant system enzymes in the pathogenesis of HAPE (high-altitude pulmonary edema) formation. We incorporated the study on 42 male rats to unravel the role of mast cells (MCs) and TNF-α in the lung after the effect of acute hypobaric hypoxia.
View Article and Find Full Text PDFHematological and thermographical changes in rat's model exposed to long-term RF modulated signals.
Open Vet J
November 2024
Department of Biology, College of Education for Women, University of Tikrit, Tikrit, Iraq.
Background: Long-term exposure to LTE signals at different frequencies has become a crucial problem in our daily life.
Aim: The aim of the study to figure out the thermal influence of LTE signals (850 MHz, 1800 MHz, and 2600 MHz) on hematological values in rat's model during different periods.
Methods: Forty adult male rats were randomly distributed into four equal groups (control, 850 MHz, 1800 MHz, and 2600 MHz exposure groups).
In vivo imaging of adipose-derived stem cell sheets on biodegradable nonwoven fabric using X-ray CT.
Biomed Eng Online
December 2024
ORTHOREBIRTH Co., Ltd., Yokohama, Japan.
Background: A biodegradable nonwoven fabric that can be used to extract adipose-derived stem cells (ADSCs) from adipose tissue slices was developed, which were cultured rapidly without enzymatic treatment. The extracted and cultured ADSCs remain on the nonwoven fabric and form a thick cell sheet. The aim was to use the thick cell sheet as a treatment by transplanting it into the living body.
View Article and Find Full Text PDF[Electroacupuncture preconditioning alleviates podocyte injury via PTEN/PI3K pathway in type 2 diabetes rats].
Zhen Ci Yan Jiu
December 2024
The Second Clinical Medicine College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Objectives: To observe the effect of electroacupuncture (EA) preconditioning on podocytes and phosphatase and tension homologous protein (PTEN)/phosphoinositide-3-kinase (PI3K) signaling pathway in rats with type 2 diabetic kidney injury, so as to explore its potential mechanisms.
Methods: Fifty male Wistar rats were randomly divided into control, model, EA, inhibitor, and sham EA groups, with 10 rats in each group. Diabetes model was established by high-fat and high-sugar diet and intraperitoneal injection of streptozotocin (40 mg/kg).
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