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Objective: Aim: To analyze the mechanisms of regulation of the body's proteolytic systems during inflammation, detection of inflammation markers in blood and prostate secretions in the experimental benign prostatic hyperplasia in rats.
Patients And Methods: Materials and Methods: The study was conducted on 30 male rats on the model of benign prostatic hyperplasia. Rats were randomized as following: the 1st group (n=6) - intact animals; the 2nd group (n=24) - rats with benign prostatic hyperplasia.
Determining the Permeability of Porous Bioceramic Scaffolds: Significance, Overview of Current Methods and Challenges Ahead.
Materials (Basel)
November 2024
Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Turin, Italy.
The "architectural suitability" of scaffolds for bone tissue engineering is commonly evaluated by assessing the pore volume and the mean pore size (or pore size distribution, if possible) and comparing these values with the reference ranges of human cancellous bone. However, these two parameters cannot precisely describe the complex architecture of bone scaffolds and just provide a preliminary comparative criterion. Permeability is suggested as a more comprehensive and significant parameter to characterize scaffold architecture and mass transport capability, being also related to bone in-growth and, thus, functional properties.
View Article and Find Full Text PDFAn integrated framework of deep learning and entropy theory for enhanced high-dimensional permeability field identification in heterogeneous aquifers.
Water Res
January 2025
Departments of Geosciences and Environmental Engineering, University of Cincinnati, Cincinnati, OH, USA.
Accurately estimating high-dimensional permeability (k) fields through data assimilation is critical for minimizing uncertainties in groundwater flow and solute transport simulations. However, designing an effective monitoring network to obtain diverse system responses in heterogeneous aquifers for data assimilation presents significant challenges. To investigate the influence of different measurement types (hydraulic heads, solute concentrations, and permeability) and monitoring strategies on the accuracy of permeability characterization, this study integrates a deep learning-based surrogate modeling approach and the entropy-based maximum information minimum redundancy (MIMR) monitoring design criterion into a data assimilation framework.
View Article and Find Full Text PDFThe effect of prebiotic fibre on the gut microbiome and surgical outcomes in patients with prosthetic joint infection (PENGUIN) - study protocol for a randomised, double-blind, placebo-controlled trial (ACTRN12623001273673).
Nutr J
October 2024
Department of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, 5000, Australia.
Background: Prosthetic Joint Infection (PJI) is the most devastating complication of arthroplasty surgery and affects 1-5% of patients. Despite strict adherence to aseptic protocols and preventive measures, infection is the most common reason for revision arthroplasty, and the incidence is increasing. Treatment of PJI is challenging and often requires repeated major surgeries with sequentially poor results.
View Article and Find Full Text PDFTowards the understanding of the IVPT results variability-Development, verification and validation of the PBPK model of caffeine in vitro human skin permeation.
Eur J Pharm Sci
January 2025
Pharmacoepidemiology and Pharmacoeconomics Unit, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, str., 30-688, Krakow, Poland. Electronic address:
In the context of evaluating the safety and efficacy of dermal products, pharmacokinetic (PK) studies face considerable challenges, particularly concerning topically applied formulations. This underscores the necessity for alternative methods, such as in vitro permeation tests (IVPT) and physiologically based pharmacokinetic (PBPK) modelling, to better understand the dermal pharmacokinetics of a product. The purpose of this study was to modify, verify, and validate the PBPK model of caffeine permeation through human skin previously developed by Patel et al.
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