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Malian field isolates provide insight into Plasmodium malariae intra-erythrocytic development and invasion.
PLoS Negl Trop Dis
January 2025
Malaria Research and Training Center (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.
Plasmodium malariae is the third most prevalent human malaria parasite species and contributes significantly to morbidity. Nevertheless, our comprehension of this parasite's biology remains limited, primarily due to its frequent co-infections with other species and the lack of a continuous in vitro culture system. To effectively combat and eliminate this overlooked parasite, it is imperative to acquire a better understanding of this species.
View Article and Find Full Text PDFA novel digestive protease chymotrypsin-like serine contributes to anti-BmNPV activity in silkworm (Bombyxmori).
Dev Comp Immunol
December 2024
Anhui Province Key Laboratory of Resource Insect Biology and Innovative Utilization, School of Life Sciences, Anhui Agricultural University, Hefei, 230036, China; Anhui International Joint Research and Developmental Center of Sericulture Resources Utilization, Hefei, 230036, China. Electronic address:
Serine proteases (SPs) are important proteases in the digestive system of lepidopteran insects. They play important roles in protein digestion, coagulation, signal transduction, hormone activation, inflammation and development. Blood-borne pyosis caused by Bombyx mori nuclear polyhedrosis virus (BmNPV) has caused serious harm to sericulture.
View Article and Find Full Text PDFFungal endophytes enhanced insect resistance by improving the defenses of Achnatherum sibiricum before locust feeding.
Pest Manag Sci
December 2024
College of Life Sciences, Nankai University, Tianjin, China.
Background: Epichloë endophytes provide many benefits to host plants, including enhanced insect resistance. Fungal alkaloids are usually thought to be responsible for the endophyte-conferred herbivore resistance. Nonetheless, the fungal alkaloid profiles and concentrations may vary considerably among grass-endophyte systems.
View Article and Find Full Text PDFIn-situ electrochemically synthesized "artificial" Gly m TI antibody for soybean allergen quantification in complex foods.
Anal Chim Acta
December 2024
Centro de Investigação em Química da Universidade do Porto/ Instituto de Ciências Moleculares (CIQUP/IMS), Faculdade de Ciências da Universidade do Porto, Departamento de Química e Bioquímica Rua do Campo Alegre 687, 4169-007, Porto, Portugal. Electronic address:
Article Synopsis
- Biosensors targeting food allergens, like Gly m TI in soybeans, enhance individual health safety and public health by facilitating compliance with food regulations and reducing allergen-related recalls.
- Recent developments in biosensor technology, like portability and real-time monitoring, broaden their applications in food production, food service, and even home environments, making them essential tools for allergen detection.
- A novel Gly m TI-MIP biosensor was successfully created to identify soybean protein in a variety of complex food matrices, achieving high sensitivity and minimizing cross-reactivity, thus improving food safety protocols for both processed and unprocessed foods.
Effect of Water Networks On Ligand Binding: Computational Predictions vs Experiments.
J Chem Inf Model
December 2024
Medicinal Chemistry Research Group, Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, Budapest 1117, Hungary.
Rational drug design focuses on the explanation and prediction of complex formation between therapeutic targets and small-molecule ligands. As a third and often overlooked interacting partner, water molecules play a critical role in the thermodynamics of protein-ligand binding, impacting both the entropy and enthalpy components of the binding free energy and by extension, on-target affinity and bioactivity. The community has realized the importance of binding site waters, as evidenced by the number of computational tools to predict the structure and thermodynamics of their networks.
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