The contact sensitivity response to DNFB is decreased after adult thymectomy (ATX). This response decreases to 50% of the control response of normal age-matched mice as soon as 3 weeks after ATX and is not further depressed 9 to 16 weeks after ATX. These results suggest that two T cell subsets of different lifespan are involved in the anti-DNFB response. A circulating thymic factor (FTS) is able to restore the contact sensitivity response to DNFB when injected 3 to 9 weeks after ATX but not 16 weeks later. By contrast, FTS has a depressive effect on the contact sensitivity response to DNFB of normal mice through a cyclophosphamide-sensitive T cell subset. These results suggest that FTS regulates DNFB contact sensitivity by acting on a cyclophosphamide-sensitive T cell subset, still present 9 weeks after ATX but absent after 16 weeks. Thus although the T cell defect, causing a depression of the contact sensitivity reaction to DNFB is quantitatively similar 3 and 16 weeks after ATX, its nature is probably different.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Highly Efficient Compositional and Compound Specific Isotopic Analysis of Volatile Primary Amines and Ammonia in the Murchison Meteorite Using SPME On-Fiber Derivatization: Optimization for Bennu Sample Analyses.
Rapid Commun Mass Spectrom
April 2025
Solar System Exploration Division, NASA Goddard Space Center, Greenbelt, Maryland, USA.
Rationale: Extraterrestrial amines and ammonia are critical ingredients for the formation of astrobiologically important compounds such as amino acids and nucleobases. However, conventional methods for analyzing the composition and isotopic ratios of volatile amines suffer from lengthy derivatization and purification procedures, high sample mass consumption, and chromatographic interferences from derivatization reagents and non-target compounds.
Methods: Here we demonstrate a highly efficient method to analyze the composition and compound specific isotopic ratios of C to C amines as well as ammonia based on solid phase micro-extraction (SPME) on-fiber derivatization.
Chlorphenesin-Induced Allergic Contact Dermatitis: An Overlooked Phenomenon?
Dermatitis
January 2025
Dermatovenereology Department, Unidade Local de Saúde de Braga, Braga, Portugal.
Colophony in Dentistry: Routes of Exposure and Reported Reactions.
Dermatitis
January 2025
Department of Dermatology, Park Nicollet Contact Dermatitis Clinic, Minneapolis, Minnesota, USA.
Colophony is a solid form of resin derived from coniferous trees that has both adhesive and water-resistant properties. For these reasons, this allergen is incorporated into many personal care products, medications, and occupational materials, and is thus commonly implicated in allergic contact dermatitis. Dedicated "dental" allergen series often include colophony, but dermatologists are likely not well-versed on its use in a dental setting.
View Article and Find Full Text PDFA Proximity and Tactile Sensor with Visual Multiresponse.
ACS Appl Mater Interfaces
January 2025
College of Integrated Circuit Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.
Proximity and tactile multiresponse sensing electronic skin enriches the perception dimension, which is of great significance in promoting the intelligence of electronic skin. However, achieving real-time visualization in sensors such as proximity and tactile feedback remains a challenge. A proximity and tactile sensor with visual function is designed, which can realize optical early warning and electrical recognition when the object is near, and optical display and electrical output when the object is in contact.
View Article and Find Full Text PDFHighly sensitive, breathable, and superhydrophobic dome structure nonwoven-based flexible pressure sensor utilizing machine learning for handwriting recognition.
Int J Biol Macromol
January 2025
Shaoxing Key Laboratory of High Performance Fibers & Products, Shaoxing University, Shaoxing, Zhejiang 312000, China; Shaoxing Sub-center of National Engineering Research Center for Fiber-based Composites, Shaoxing University, Zhejiang, Shaoxing 312000, China; Key Laboratory of Clean Dyeing and Finishing Technology of Zhejiang Province, Shaoxing, Zhejiang 312000, China. Electronic address:
Wearable devices that incorporate flexible pressure sensors have shown great potential for human-machine interaction, speech recognition, health monitoring, and handwriting recognition.However, achieving high sensitivity, durability, wide detection range, and breathability through cost-effective fabrication remains challenging. Through ultrasound-assisted modification and impregnation-drying, dome-structured nonwovens/rGO/PDMS flexible pressure sensors were developed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!