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Vaccine effectiveness in patients admitted for influenza during the 2023-2024 season.
Med Clin (Barc)
December 2024
Sección de Enfermedades Infecciosas, Hospital General Universitario Reina Sofía, Murcia, España; Inmunología, Microbiología y Enfermedades Infecciosas, Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (IMIB), Murcia, España; Departamento de Medicina Interna, Facultad de Medicina, Universidad de Murcia, Murcia, España.
Background And Goal: Vaccination against influenza is widespread worldwide, reducing complications associated with infection. However, the impact of vaccination on mortality/ICU admission in hospitalized patients has been little studied.
Material And Methods: A retrospective observational study was conducted on 238 patients hospitalized for influenza from October 2023 to January 2024 to evaluate the vaccine's effectiveness in terms of the combined event of ICU admission/mortality during hospitalization.
Contribution of intramacrophage stages to Pseudomonas aeruginosa infection outcome in zebrafish embryos: insights from mgtC and oprF mutants.
Sci Rep
March 2024
Laboratory of Pathogens and Host Immunity (LPHI), Université de Montpellier, CNRS-UMR5294, INSERM, Montpellier, France.
Pseudomonas aeruginosa often colonizes immunocompromised patients, causing acute and chronic infections. This bacterium can reside transiently inside cultured macrophages, but the contribution of the intramacrophic stage during infection remains unclear. MgtC and OprF have been identified as important bacterial factors when P.
View Article and Find Full Text PDFPrognostic impact of chronic obstructive pulmonary disease and bronchial asthma in patients with heart failure.
Rev Clin Esp (Barc)
March 2024
Servicio de Cardiología, Complejo Hospitalario Universitario de A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), Servicio Galego de Saúde (SERGAS), A Coruña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Universidad de A Coruña (UDC), A Coruña, Spain.
Purpose: To analyze the impact of chronic obstructive pulmonary disease (COPD) and bronchial asthma on therapeutic management and prognosis of patients with heart failure (HF).
Methods: Analysis of the information collected in a clinical registry of patients referred to a specialized HF unit from January-2010 to June-2012. Clinical profile, treatment and prognosis of patients was evaluated, according to the presence of COPD or asthma.
Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.
Cell Rep
June 2022
Institut Pasteur, Université de Paris, Malaria Parasite Biology and Vaccines Unit, Paris, France. Electronic address:
The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate that Plasmodium falciparum imports a host antioxidant enzyme, peroxiredoxin 6 (PRDX6), during hemoglobin uptake from the red blood cell cytosol.
View Article and Find Full Text PDFNovel Anti-Inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies.
Front Pharmacol
July 2020
Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Cystic fibrosis (CF) is the most common genetic disorder among Caucasians, estimated to affect more than 70,000 people in the world. Severe and persistent bronchial inflammation and chronic bacterial infection, along with airway mucus obstruction, are hallmarks of CF lung disease and participate in its progression. Anti-inflammatory therapies are, therefore, of particular interest for CF lung disease.
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