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Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Cryobiology
January 2025
Reproductive Medical Center of Nanning Second People's Hospital, Nanning, Guangxi 530031, China. Electronic address:
For infertile patients who are unable to obtain sperm or prepubertal boys who require radiotherapy, testicular tissue freezing can be used for later transplantation and is a potentially effective method of preserving male fertility. Oxidative stress caused by the freezing process is an important cause of tissue damage. Procyanidin B2 (PCB2) is a polyphenolic natural compound widely distributed in plants that is known for its anti-inflammatory, anticancer, and neuroprotective properties, and its antioxidant capabilities are particularly noteworthy.
View Article and Find Full Text PDFThe effect of coadministration of vitamin D and tramadol on serum kisspeptin, testosterone, oxidative stress levels and testicular histology in Wistar rats: a preliminary report.
Rev Int Androl
December 2024
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.O. Box 5001, 435101 Nnewi, AN, Nigeria.
Background: Tramadol, an opioid analgesic, is known to induce testicular damage and impair reproductive parameters. Vitamin D3, recognized for its antioxidant and protective properties, might offer a potential protective effect against tramadol-induced testicular damage. This study observed the effects of co-administration of vitamin D3 and tramadol on serum kisspeptin levels, testicular histology, semen parameters, testosterone levels, and oxidative stress markers in male rats.
View Article and Find Full Text PDFSafranal ameliorates testicular ischemia-reperfusion injury in testicular torsion-detorsion rat model.
Rev Int Androl
December 2024
Department of Sports Science, College of Education, Zhejiang University, 310058 Hangzhou, Zhejiang, China.
Background: Testicular torsion-detorsion damage is a common ischemia-reperfusion injury brought on by an excess of reactive oxygen species. Reactive oxygen species may affect cellular differentiation by regulating gene expression. The gene expression in the testis is essential for spermatogenesis.
View Article and Find Full Text PDFHeterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats.
Sci Rep
January 2025
Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Tumor suppressor BRCA2 executes homologous recombination to repair DNA double-strand breaks in collaboration with RAD51, involving exon 11 and 27. Exon 11 constitutes a region where pathogenic variants (PVs) accumulate, and mutations in this region are known to contribute to carcinogenesis. However, the impact of the heterozygous PVs of BRCA2 exon 11 on the life quality beyond cancer risk, including male fertility, remains unclear.
View Article and Find Full Text PDFCep78 knockout causes sterility and oligoasthenoteratozoospermia in male mice.
Sci Rep
January 2025
The Affiliated Taian City Central Hospital of Qingdao University, 29 Longtan Rd, Taishan District, Taian, 271000, Shandong, China.
Oligoasthenoteratozoospermia (OAT) is a common cause of infertility among males, and the majority of cases of idiopathic OAT are thought to be attributed to genetic defects. In this study, the role of the CEP78 protein in spermatogenesis was initially investigated using Cep78 knockout (Cep78) mice. Notably, the male Cep78 mice exhibited the OAT phenotype and sterility.
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