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Potential of Liposomal FTY720 for Bone Regeneration: Proliferative, Osteoinductive, Chemoattractive, and Angiogenic Properties Compared to Free Bioactive Lipid.
Int J Nanomedicine
January 2025
Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion, 26504, Greece.
Introduction: FTY720 bioactive lipid has proliferative, osteoinductive, chemo attractive, and angiogenic properties, being thus a potential exogenous administered agent for promotion of bone regeneration. Herein we developed FTY720-loaded liposomes as a potential delivery system that could retain and prolong the bioactivity of the bioactive lipid and at the same time reduce its cytotoxicity (at high doses).
Methods: FTY720 liposomes were prepared by thin-lipid hydration and microfluidic flow focusing, and evaluated for their ability to induce proliferation, osteoinduction, and chemoattraction in three cell types: MC3T3-E1 pre-osteoblast cells, L929 fibroblast cells, and ATDC5 chondrogenic cells.
Fibroblast Growth Factor 8 enhances the chondrogenesis of trunk neural crest cells: a possible gene regulatory network.
Int J Dev Biol
December 2024
Laboratory of Plasticity and Differentiation of Neural Crest Cells, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
The neural crest (NC) is an embryonic cell population with high migratory capacity. It contributes to forming several organs and tissues, such as the craniofacial skeleton and the peripheral nervous system of vertebrates. Both pre-migratory and post-migratory NC cells are plastic, adopting multiple differentiation paths by responding to different inductive environmental signals.
View Article and Find Full Text PDFCategorization of early embryonic malformations in broilers by a new classification method combining light microscopy and high-resolution Episcopic Microscopy.
Poult Sci
November 2024
Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agricultural, Food, and Environmental Sciences, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel. Electronic address:
Hatchability rates in broilers pose a significant challenge in the poultry industry. Despite advancements in breeding and incubation technology, hatch rates remain suboptimal due to factors like genetics, egg management, environmental stress, nutrition, and breeder age. Understanding the mechanisms behind compromised hatchability is crucial for improving broiler production.
View Article and Find Full Text PDFFabrication and evaluation of Zn-EGCG-loaded chitosan scaffolds for bone regeneration: From cellular responses to in vivo performance.
Int J Biol Macromol
December 2024
Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 12100, China. Electronic address:
We have synthesized a flavonoid metal complex (FMC) by chelating zinc to epigallocatechin-3-gallate (EGCG), a flavonoid present in green tea and incorporated into chitosan (CS) to form 3D constructs by freeze drying method. Scanning electron microscopy characterized The scaffolds for surface morphology and pore dimensions and depicted the presence of interconnected porous network. The scaffolds exhibited optimal pore size (>50 μm), facilitating bone tissue ingrowth and neovascularization.
View Article and Find Full Text PDFPrenatal Maternal Stress Suppresses Embryonic Neurogenesis via Elevated Glucocorticoid Levels.
Endocrinology
October 2024
Division of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou 510632, China.
Although it is known that prenatal maternal stress (PNMS) has a negative influence on nervous system development in offspring, there is no conclusive evidence clarifying its impact on early neurogenesis during development. In this study, we established a chick embryo model to investigate how PNMS affects early neurogenesis by mimicking an intrauterine environment with elevated dexamethasone levels. The results showed that dexamethasone-mimicked PNMS significantly suppressed the development of gastrula embryos and increased the risks of neural tube defects and cranial deformity.
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