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Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.
Front Endocrinol (Lausanne)
January 2025
School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China.
Objective: Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. While multiple studies have indicated changes in the expression of specific matrix metalloproteinases (MMPs) in patients with DN, and basic research has reported the impact of MMPs on DN, there is a lack of systematic research and the causal relationship remains unclear. The objective of this research is to investigate the casual relationship between MMPs and DN through two-sample Mendelian randomization (MR).
View Article and Find Full Text PDFRelationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study.
Front Endocrinol (Lausanne)
January 2025
Department of Plastic Surgery, the First Affiliated Hospital of Air Force Medical University, Xi'an, China.
Objective: Diabetic foot ulcer (DFU) is one of the common complications in patients with diabetes mellitus (DM). In order to find a method to monitor and treat the refractory DFU, the ferroptosis level in DFU and traumatic wounds (TW) was monitored and the difference between them was analyzed. At the same time, this study further analyzed the correlation of ferroptosis levels with DM severity and DFU's healing.
View Article and Find Full Text PDFMetformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway.
Arch Endocrinol Metab
January 2025
Fuzhou First General Hospital Affiliated with Fujian Medical University Department of Endocrinology FuzhouFujian China Department of Endocrinology, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, China.
Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes.
View Article and Find Full Text PDFImplementation of a clinical pathway for diabetes-related foot ulcers reduced the number of amputations and shortened hospital stay.
J Foot Ankle Res
March 2025
Department of Orthopaedic Surgery, Akershus University Hospital, Lørenskog, Norway.
Introduction: Diabetes-related foot ulcer (DFU) is the leading cause for lower extremity amputations (LEAs) in western countries, and may cause social isolation, depression, and death. However, people with DFU are not offered the same prioritized care as cancer patients, despite comparable mortality rates. We therefore decided to create a clinical pathway for patients with DFU.
View Article and Find Full Text PDFThe Role of Serum HMGB-1 Level in Differentiating the Soft-Tissue Infection From Diabetic Foot Osteomyelitis.
J Am Podiatr Med Assoc
January 2025
†Medical Point Gaziantep Hospital, Gaziantep, Turkey.
Background: The incidence of diabetic foot infections is increasing due to the rising number of persons with diabetes and the prolonged life expectancy. It is vital to differentiate soft-tissue infection (STI) from diabetic foot osteomyelitis (DFO), as treatment modalities and durations vary widely, but this can be challenging. We aimed to assess the blood concentration levels of the high mobility group box 1 protein (HMGB-1) in STI and DFO compared to healthy subjects, and to investigate whether this protein could contribute to differentiating STI from DFO.
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