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Subcytotoxic transepidermal delivery using low intensity cold atmospheric plasma.
Sci Rep
January 2025
Department of Dermatology, Chung-Ang University Hospital, 102, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea.
Cold atmospheric plasma (CAP) has been utilized in various medical devices using its oxidative nature. Recent studies have provided evidence that CAP can facilitate the delivery of large, hydrophilic molecules through the epidermis to the dermis. On the other hand, a new approach called low-intensity CAP (LICAP) has been developed, allowing the plasma level to be controlled within a subtoxic range, thereby demonstrating various biological benefits without tissue damage.
View Article and Find Full Text PDFComparative Evaluation of Deciduous and Permanent Coronal Caries Using Polarizing Light Microscopy and Scanning Electron Microscopy.
ScientificWorldJournal
January 2025
Department of Prosthodontics, Indira Gandhi Institute of Dental Sciences, Nellikuzhi, Kothamangalam 686691, Kerala, India.
Dental caries causes mineral loss and organic damage to teeth. Understanding caries and dentin pulp reactions is crucial for effective caries management strategies. There is a lack of knowledge regarding the microscopic and ultramicroscopic changes that occur during caries destruction and reactive changes.
View Article and Find Full Text PDFObjective: At the histological and ultramicroscopic level, compare biopsy specimens of donor heart under standard (up to 240 min) and extended (more than 240 min) periods of pharmaco-cold preservation.
Material And Methods: Biopsy specimens of the left atrium of donor hearts: group 1 - 8 samples after transportation with pharmaco-cold preservation of the graft in Bretschneider solution (Dr. Franz Köhler Chemie GmbH, Germany) up to 240 min, (Me 140), and group 2 - 5 samples after an extended pharmaco-cold period (more than 240 min; Me 375) were examined using light microscopy of semi-thin sections and transmission electron microscopy, followed by stereological and statistical analysis.
Study of the relationships among known virulence genes, coccoid transformation and cytotoxicity of in different clinical diseases.
Virulence
December 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Article Synopsis
- This study identifies the disconnect between known virulence genes and the infectivity of a certain strain that has infected approximately 4.4 billion people globally.
- Researchers used whole-gene sequencing and microscopy to analyze 35 strains, observing no significant relationship between virulence genes, coccoid transformation, and cytotoxicity in various clinical cases.
- The findings led to the development of a new virulence classification based on the strain's ability to defend and attack, though further verification of its correlation with pathogenic ability is still needed.
Designer pseudopeptides: autofluorescent polygonal tubes Phe-zipper and triple helix.
Chem Sci
September 2024
Department of Chemistry, Indian Institute of Technology Delhi Hauz Khas New Delhi-110016 India
Chemists are increasingly turning to biology for inspiration to develop novel and superior synthetic materials. Here, we present an innovative peptide design strategy for tubular assembly. In this simple design, a phenylene urea unit is introduced as an aglet at the N-terminus of the peptide.
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