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Identification of novel serum lipid metabolism potential markers and metabolic pathways for oral cancer: a population-based study.
BMC Cancer
January 2025
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, 1 Xueyuan Road, Fujian, 350108, China.
Objective: This study aims to identify potential lipid biomarkers and metabolic pathways associated with oral cancer (OC). Then to establish and evaluate disease classification models capable of distinguishing OC patients from healthy controls.
Methods: A total of 41 OC patients and 41 controls were recruited from a hospital in Southeast China to examine the serum lipidomics by Ultra-high Performance Liquid Chromatography Q Exactive Mass Spectrometry (UHPLC-QE-MS).
Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer.
BMC Gastroenterol
January 2025
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230022, China.
Background: Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects the normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles and join into the progression of multiple diseases. However, the regulatory impacts and associated molecular mechanisms of AG in CRC progression keep unclear.
View Article and Find Full Text PDFLipidomic profiling reveals the protective mechanism of nitrogen-controlled atmosphere on brown rice quality during storage.
Food Chem
January 2025
College of Food Science and Engineering, Nanjing University of Finance and Economics/ Collaborative Innovation Center for Modern Grain Circulation and Safety, NO.3 Wenyuan Road, Xixia District, Nanjing 210023, Jiangsu, China. Electronic address:
Rice, a globally important staple, requires effective preservation methods to maintain its quality during extended storage. This study explored the efficacy of nitrogen-controlled atmosphere (NCA) storage in preserving the quality of brown rice during a one-year period using UHPLC-MS/MS based lipidomic profiling. A total of 1013 lipids were identified and categorized into five main groups.
View Article and Find Full Text PDFFirst-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls.
Front Mol Biosci
January 2025
Division of Maternal and Fetal Medicine, Fundación Para la Investigación Biomédica, La Paz University Hospital, Madrid, Spain.
Introduction: Gestational diabetes mellitus (GDM) is a global health concern with significant short and long-term complications for both mother and baby. Early prediction of GDM, particularly late-onset, is crucial for implementing timely interventions to mitigate adverse outcomes. In this study, we conducted a comprehensive metabolomic analysis to explore potential biomarkers for early GDM prediction.
View Article and Find Full Text PDFPivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization.
Commun Biol
January 2025
Department of Cellular Architecture Studies, Division of Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
The rapid intraerythrocytic replication of Plasmodium falciparum, a deadly species of malaria parasite, requires a quick but constant supply of phospholipids to support marked cell membrane expansion. In the malarial parasite, many enzymes functioning in phospholipid synthesis pathway have not been identified or characterized. Here, we identify P.
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