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Prediction of HIF-1α expression in endometrial carcinoma by enhanced T weighted angiography and dynamic contrast-enhanced magnetic resonance imaging.
Front Oncol
December 2024
Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Purpose: To explore the value of quantitative imaging parameters by enhanced T weighted angiography (ESWAN) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for evaluating the expression of Hypoxia-inducible factor-1α (HIF-1α) in endometrial carcinoma (EC).
Methods: Data from 122 patients with EC confirmed by clinical pathology were retrospectively analyzed. According to the number of positive cells stained with HIF-1α by immunohistochemistry, patients were divided into two groups: 65 cases with high expression of HIF-1α and 57 cases with low expression of HIF-1α.
The Fatty Dilemma: A Rare Instance of Extra- and Intravascular Lipoma of the Brachiocephalic Vein.
Indian J Radiol Imaging
January 2025
Department of Radiodiagnosis, Continental Hospitals, Hyderabad, Telangana, India.
Oftentimes, incidental findings are made on routine diagnostic imaging. An intra- and extravascular lipoma is one example of an important incidental finding. Intravascular lipomas are rare benign vascular tumors that are typically asymptomatic.
View Article and Find Full Text PDFInducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis.
J Clin Invest
October 2024
Division of Thoracic Surgery/Canning Thoracic Institute, Feinberg School of Medicine, Northwestern University/Northwestern Medicine, Chicago, Illinois, USA.
A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for the promotion of metastasis and resistance to immunosurveillance. In the circulation, some CCR2-expressing classical monocytes lose CCR2 and differentiate into intravascular nonclassical monocytes that have anticancer properties but are unable to access extravascular tumor sites.
View Article and Find Full Text PDFBlood-brain barrier breakdown in dementia with Lewy bodies.
Fluids Barriers CNS
September 2024
Department of Neurology, Tianjin Dementia Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300350, People's Republic of China.
Article Synopsis
- The study investigates the relationship between blood-brain barrier (BBB) dysfunction and dementia, particularly focusing on dementia with Lewy bodies (DLB) compared to Alzheimer's disease (AD).
- Using dynamic contrast-enhanced MRI, the researchers measured BBB permeability in healthy controls and patients with AD and DLB and found significant differences in BBB dysfunction between DLB, AD, and healthy individuals.
- Results indicated increased BBB permeability in DLB patients, particularly in the cerebral cortex and occipital lobe, which was associated with higher clinical dementia ratings and elevated plasma amyloid-β levels, suggesting a connection between BBB dysfunction and the severity of dementia symptoms.
A Randomized Trial Comparing Imlifidase to Plasmapheresis in Kidney Transplant Recipients With Antibody-Mediated Rejection.
Clin Transplant
July 2024
Cedars-Sinai Medical Center, Los Angeles, California, USA.
Background: Antibody-mediated rejection (ABMR) poses a barrier to long-term graft survival and is one of the most challenging events after kidney transplantation. Removing donor specific antibodies (DSA) through therapeutic plasma exchange (PLEX) is a cornerstone of antibody depletion but has inconsistent effects. Imlifidase is a treatment currently utilized for desensitization with near-complete inactivation of DSA both in the intra- and extravascular space.
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