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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis.
Cancer Metab
January 2025
Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim, 68167, Germany.
Background: In malignant melanoma, liver metastases significantly reduce survival, even despite highly effective new therapies. Given the increase in metabolic liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), this study investigated the impact of liver sinusoidal endothelial cell (LSEC)-specific alterations in MASLD/MASH on hepatic melanoma metastasis.
Methods: Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated liver fibrosis, or a CDAA diet or a high fat diet (HFD) for shorter periods of time to induce early steatosis-associated alterations.
Postauricular feather foreign body in an infant.
BMJ Case Rep
January 2025
Ear, Nose and Throat, James Cook University Hospital, Middlesbrough, UK.
A male infant presented with reduced oral intake, low-grade fever and postauricular erythema. Clinical examination revealed a soft, tender swelling posteroinferior to the mastoid tip with a dull tympanic membrane on otoscopy. Cross-sectional imaging did not show any evidence of middle ear infection or mastoiditis.
View Article and Find Full Text PDFContaminant-Associated Disruption of the Skin Transcriptome in the Endangered St. Lawrence Estuary Beluga.
Environ Sci Technol
January 2025
Fisheries and Oceans Canada, Pacific Science Enterprise Center, 4160 Marine Drive, West Vancouver, British Columbia V7V 1N6, Canada.
The St. Lawrence Estuary (SLE) beluga () population in Canada is Endangered, and endocrine disrupting contaminants, such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and other halogenated flame retardants, have been identified as a threat to the recovery of this population. Here, potential impacts of these contaminants on SLE beluga were evaluated by comparing skin transcriptome profiles and biological pathways between this population and a population less exposed to contaminants (Eastern Beaufort Sea) used as a reference.
View Article and Find Full Text PDFUse of Electronic Health Records to Identify Factors Related to Skin Changes in Terminal Patients.
Adv Skin Wound Care
January 2025
Chia-Jung Chan, MS, RN, is Head Nurse, Taipei Medical University Hospital, Taipei, Taiwan. Yeu-Hui Chuang, PhD, RN, is Professor, School of Nursing, College of Nursing, Taipei Medical University, and Researcher, Research Center in Nursing Clinical Practice, Wan Fang Hospital, Taipei Medical University; Tsai-Wei Huang, PhD, RN, is Professor, School of Nursing, College of Nursing. Taipei Medical University, and Researcher, Research Center in Nursing Clinical Practice, Wan Fang Hospital, Taipei Medical University; Made Satya Nugraha Gautama, S.Kep, Ns, is Lecturer, Department of Nursing, Faculty of Medicine, Universitas Pendidikan Ganesha, Bali, Indonesia.
Objective: To investigate the incidence of skin changes at life's end (SCALE) among hospice patients and identify associated factors.
Methods: The authors conducted a retrospective chart review of demographic data, medical history, Braden Scale assessment scores, Charlson Comorbidity Index, symptom records, and medical treatments of patients admitted to a local teaching hospital's hospice unit between May 2019 and April 2021.
Results: Most (79%) of the 300 hospice patients included in the study had cancer.
Highly deformable flapping membrane wings suppress the leading edge vortex in hover to perform better.
Proc Natl Acad Sci U S A
February 2025
École polytechnique fédérale de Lausanne, School of Engineering, Institute of Mechanical Engineering, Unsteady Flow Diagnostics Laboratory, Lausanne 1015, Switzerland.
Airborne insects generate a leading edge vortex when they flap their wings. This coherent vortex is a low-pressure region that enhances the lift of flapping wings compared to fixed wings. Insect wings are thin membranes strengthened by a system of veins that does not allow large wing deformations.
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