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Molecular mechanism of amygdalin action in vitro: review of the latest research.
Immunopharmacol Immunotoxicol
June 2018
a Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection , University of Lodz, Lodz , Poland.
Amygdalin, named as 'laetrile' and 'vitamin B-17' was initially supposed to be a safe drug for cancer treatment and was recognized by followers of natural medicine since it has been considered to be hydrolyzed only in cancer cells releasing toxic hydrogen cyanide (HCN), and thus destroying them. Unfortunately, current studies have shown that HCN is also released in normal cells, therefore it may not be safe for human organism. However, there have still been research works conducted on anti-cancer properties of this compound.
View Article and Find Full Text PDFInhibitory effects of lanthanum chloride on extracellular matrix in injury tissues of rats.
Burns
November 2006
Jiangxi Province Key Laboratory of Molecular Medicine and Stem Cell Center, Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006, PR China.
The propose of the present study is to investigate the effects of lanthanum chloride (LaCl(3)), a rare earth compound, on extracellular matrix molecules in rat wound tissues, hoping to provide a clue for further study in reducing excessive extracellular matrix formation in trauma and burn, as well as in fibrous disorders. In order to elucidate its action mechanism, we investigated its effects on fibroblast apoptosis, intracellular calcium, collagen synthesis and expression, and fibronectin mRNA expression. We found that treatment with 0.
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