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Catalytic -Alkylation of (Hetero)Aromatic Amines and Tandem Annulation Reactions.
J Org Chem
October 2024
Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati - 517507, India.
A general and practical approach for -alkylation of heteroaromatic amines with heteroaromatic alcohols is always challenging and rarely reported. Here, we designed and synthesized phosphine-free, robust, and efficient N,N-bidentate-Co(II) complexes for a universal -alkylation of amines strategy. This present catalytic methodology can be applied to a wide range of substrates by varying alcohols, including aryl, aliphatic, acyclic, and cyclic groups, with heteroaromatic amines such as aminopyridine, 2-aminopyrimidine, and aminoquinoline to provide diverse monoalkylated organonitrogen compounds in good to excellent yields (108 examples).
View Article and Find Full Text PDFEnzyme Inhibitory Activities and RP-HPLC Analysis of Geranium and Erodium Species.
Chem Biodivers
October 2024
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, 06330, Türkiye.
The genera Geranium and Erodium (Geraniaceae) have been documented to possess diverse ethnopharmacological uses, including diabetes mellitus. Relevant to their ethnopharmacological use, the current study aimed to evaluate the α-glucosidase, α-amylase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzyme inhibitory activity of ethanol extracts from 46 samples belonging to thirty-one species of Geranium (20) and Erodium (11) collected throughout Türkiye. The majority of the extracts displayed a marked α-glucosidase and α-amylase inhibitory activity.
View Article and Find Full Text PDFSeizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine A receptor agonist as an adjunct to standard medical treatment.
Toxicol Appl Pharmacol
July 2024
Neuroscience Department, Medical Toxicology Research Division, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA. Electronic address:
Article Synopsis
- - Soman causes harmful excitotoxic effects by blocking acetylcholinesterase, leading to prolonged seizures (SSE) and brain damage in models.
- - A study tested the delayed use of the adenosine receptor agonist ENBA alongside current treatments (atropine, 2-PAM, midazolam) in rats, finding that ENBA improved seizure termination and reduced brain damage compared to midazolam alone.
- - Despite the benefits in seizure control and neuroprotection, the combination of ENBA with midazolam resulted in lower survival rates after 14 days, suggesting that ENBA may enhance midazolam's harmful effects on neurons, requiring careful dosage adjustments.
Learning and memory function preserved by delayed A adenosine receptor agonist treatment following soman intoxication in rats and a humanized esterase mouse model.
Neuropharmacology
August 2024
Medical Toxicology Research Division, U.S. Army Medical Research Institute of Chemical Defense, 8350 Ricketts Point Road, Aberdeen Proving Ground, MD, 21010-5400, USA. Electronic address:
Exposure to organophosphorus compounds, such as soman (GD), cause widespread toxic effects, sustained status epilepticus, neuropathology, and death. The A adenosine receptor agonist N-bicyclo-(2.2.
View Article and Find Full Text PDFAcetylcholine triggered enzymatic cascade reaction based on FeS nanoflakes catalysis for organophosphorus pesticides visual detection.
Anal Chim Acta
May 2024
Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, PR China. Electronic address:
Article Synopsis
- * The proposed method incorporates FeS nanoflakes into an enzymatic reaction, where OPs act as inhibitors, enabling sensitive and efficient detection of pesticides like dimethoate, with detection limits as low as 0.05 μg/mL.
- * This new technique not only provides accurate measurements but also allows for visual detection using smartphones, making it a promising, simple, and instrument-free approach for monitoring pesticide residues in the environment and biosecurity fields.
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