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The role of MMP-14 in ovarian cancer: a systematic review.
J Ovarian Res
August 2021
Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, the Netherlands.
Aim: In order to evaluate the role of MMP-14 in ovarian cancer, a systematic review was conducted.
Methods: In March 2020, a search in Pubmed was performed with MMP-14 and ovarian cancer as search terms. After exclusion of the references not on MMP-14 or ovarian cancer or not in English, the studies found were classified into two categories: basic research and clinicopathological research.
IGFBP3 gene promoter methylation analysis and its association with clinicopathological characteristics of colorectal carcinoma.
Mol Biol Rep
September 2020
Department of Biotechnology, School for Bio-Science and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, India.
Promoter methylation mediated silencing of tumor suppressor genes plays an important role in the tumorigenesis of colorectal carcinoma (CRC). Tumor suppressor gene, Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) expression is frequently downregulated in CRC due to promoter methylations. The aim of this study was to analyze the methylation status of IGFBP-3 gene promoter in stage II and III of CRC cases; find its association with clinicopathological characteristics of CRC patients and the methylation patterns as a prognostic biomarker.
View Article and Find Full Text PDFRegional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism.
Balkan Med J
January 2017
Department of General Surgery, Marmara University School of Medicine, İstanbul, Turkey.
Article Synopsis
- - The study explored how geographical differences impact the clinical presentation and surgical outcomes of patients with primary hyperparathyroidism (pHPT) across three regions: Black Sea, Mediterranean, and Anatolia.
- - Data from 694 patients across 23 centers indicated that the median age was 54, with 25% being asymptomatic; significant variations emerged in preoperative symptoms, serum calcium levels, and adenoma sizes depending on the region.
- - Findings suggest that environmental factors related to different habitats influence the clinicopathological characteristics of pHPT patients, with South-East Anatolia showing all symptomatic patients, while Bulgaria had the largest adenoma sizes and highest calcium levels.
Large B-cell lymphomas in adolescents and young adults in comparison to adult patients: a matched-control analysis in 55 patients.
Leuk Lymphoma
August 2014
Department of Hematology, Institut J. Paoli-I. Calmettes, Université de la Méditerranée, Marseille , France.
The aim of our study was to assess whether large B-cell lymphoma (LBCL) in adolescents and young adults (AYA) should be considered as a clinocopathological entity, and to evaluate the prognostic value of age. Fifty-five patients aged > 15-30 years were fully matched to 365 adult patients aged 31-65 years. We found a high incidence of primary mediastinal thymic LBCL subtype (33% vs.
View Article and Find Full Text PDFRare mutations in the PIK3CA gene contribute to aggressive endometrial cancer.
DNA Cell Biol
February 2010
1 Department of Chemistry and Biochemistry, Medical University-Sofia, Sofia, Bulgaria.
The molecular basis of endometrial cancer (EC), a common gynecologic malignancy, often includes mutational activation of the PIK3CA and KRAS genes. We aimed to determine the distribution of mutations in the two genes depending on patient clinocopathological characteristics. We sequenced exon 1 of the KRAS gene and exons 9 and 20 of the PIK3CA gene in 108 consecutive EC tumor samples.
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