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Human acute poisoning incidents associated with neonicotinoid pesticides in the U.S. Incident Data System (IDS) database from 2018-2022 - frequency and severity show public health risks, regulatory failures.
Environ Health
November 2024
Natural Resources Defense Council, 20 N Wacker Dr #1600, Chicago, IL, 60606, USA.
Article Synopsis
- Neonicotinoid pesticides, widely used around the world, are neurotoxic and are found in various environments, including food and water sources.
- An analysis of U.S. EPA data reported 842 non-occupational poisoning incidents linked to these pesticides from 2018 to 2022, with significant cases resulting in major illnesses and fatalities primarily associated with specific products.
- The study calls for the EPA to utilize its authority to revoke unsafe pesticide uses, emphasizing the importance of preventing neurotoxicity linked to these substances.
Exposure to nicotine and withdrawal in Wistar rats: an electrophysiological study.
Nicotine Tob Res
October 2024
Laboratory of the Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará.
Article Synopsis
- Smoking is a leading cause of preventable death globally, with nicotine affecting brain activity related to addiction and heart function, potentially leading to heart rhythm issues.
- A study was conducted on Wistar rats to examine EEG and ECG patterns during nicotine exposure, withdrawal, and relapse, focusing on the impact on brainwaves and heart conduction.
- Findings reveal that high-frequency brainwaves relate to nicotine dependence, while withdrawal emphasizes slower brain oscillations tied to cravings; nicotine can cause heart abnormalities that slightly improve with withdrawal but worsen during relapse.
Targeted delivery of the metastasis-specific tumour homing TMTP1 peptide to non-small-cell lung cancer (NSCLC) using inhalable hybrid nano-assemblies.
J Mater Chem B
October 2024
Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab, 140306, India.
Lung cancer is one of the most fatal malignancies, with the highest death rate (∼19%), and the NSCLC type accounts for ∼85% of lung cancers. In the search for new treatments, antimicrobial peptides have received much attention due to their propensity for selective destruction of cancer cells. In the current study, we evaluated the efficacy of the metastasis-specific tumour-homing-TMTP1 peptide against lung cancer using inhalable hybrid nano-assemblies of the PEG-PLGA copolymer as a carrier for pulmonary delivery which was assessed for aerodynamic and physicochemical properties, along with the peptide-release profile, physical stability, cellular uptake and biocompatibility, generation of reactive oxygen species, cell migration, autophagic flux, and apoptotic cell death in A549 lung cancer cells.
View Article and Find Full Text PDFAssociation of Life's Essential 8 With Incident Cardiovascular Disease Among Individuals With Depression: A Prospective Study.
Can J Cardiol
December 2024
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, and Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangdong, China. Electronic address:
Background: Depression is an increasing illness worldwide that severely diminishes the quality of life. In this study we sought to elucidate the association of the American Heart Association's Life's Essential 8 (LE8) metrics with the incidence of cardiovascular disease (CVD) among depression participants and further quantify the related theoretical reduction of long-term CVD burden.
Methods: We included 20,832 participants with depression from the UK Biobank.
MiR-1909-5p targeting GPX4 affects the progression of aortic dissection by modulating nicotine-induced ferroptosis.
Food Chem Toxicol
September 2024
Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China. Electronic address:
Objective: Aortic dissection (AD) is a prevalent and acute clinical catastrophe characterized by abrupt manifestation, swift progression, and elevated fatality rates. Despite smoking being a significant risk factor for AD, the precise pathological process remains elusive. This investigation endeavors to explore the mechanisms by which smoking accelerates AD through ferroptosis induction.
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