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Unlabelled: Antibiotic resistance is a global crisis that stems from the use of antibiotics as an essential part of modern medicine. Understanding how antibiotic resistance is controlled among cells in bacterial populations will provide insights into how antibiotics shape microbial communities. Here, we describe patterns of gene expression that arise from growth on a surface either in isolation or under subinhibitory chloramphenicol exposure.

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Novel D-Ribofuranosyl Tetrazoles: Synthesis, Characterization, In Vitro Antimicrobial Activity, and Computational Studies.

ACS Omega

January 2025

Applied Chemistry and Environment Laboratory, Applied Bioorganic Chemistry Team, Faculty of Science, Ibn Zohr University, Agadir 80000, Morocco.

The goal of this study was to synthesize and evaluate new antimicrobial compounds. We specifically focused on the development of 2,5-disubstituted tetrazole derivatives containing the O-methyl-2,3-O-isopropylidene-(D)-ribofuranoside groups through N-alkylation reactions. The synthesized compounds were characterized using H and C nuclear magnetic resonance (NMR) spectroscopy.

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Antibacterial Efficacy Comparison of Electrolytic and Reductive Silver Nanoparticles Against .

Antibiotics (Basel)

January 2025

Department of Physics Education, Faculty of Mathematics and Science, Universitas Negeri Yogyakarta, 1st Colombo St., Karangmalang, Sleman, Yogyakarta 55281, Indonesia.

The aim of this study was to develop an electrolysis system to produce silver nanoparticles free from toxic gases, as the most common reduction and electrolysis techniques produce nitrogen dioxide (NO) as a byproduct, which is harmful to human health. The new electrolysis system used two identical silver plate electrodes, replacing silver and carbon rods, and used water as the electrolyte instead of silver nitrate (AgNO) solution since AgNO is the source of NO. The electrolytic silver nanoparticles (ESNs) produced by the new system were characterized and compared with reductive silver nanoparticles (RSNs).

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Recently, the extensive use of antibiotics has unavoidably resulted in the discharge of significant quantities of these drugs into the environment, causing contamination and fostering antibiotic resistance. Among various approaches employed to tackle this problem, heterogeneous photocatalysis has emerged as a technique for antibiotic degradation. This study explores the potential of CeO as a photocatalyst for the degradation of chloramphenicol.

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Bimetallic metal-organic frameworks as electrode modifiers for enhanced electrochemical sensing of chloramphenicol.

Mikrochim Acta

January 2025

Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, College of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, China.

An electrochemical sensor is presented for the detection of the chloramphenicol (CAP) based on a bimetallic MIL-101(Fe/Co) MOF electrocatalyst. The MIL-101(Fe/Co) was prepared by utilizing mixed-valence Fe (III) and Co (II) as metal nodes and terephthalic acid as ligands with a simple hydrothermal method and characterized by SEM, TEM, XRD, FTIR, and XPS. Electrochemical measurements such as electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) showed that bimetallic MIL-101(Fe/Co) had the faster electron transfer, larger electroactive area, and higher electrocatalytic activity compared with  their monometallic counterparts due to the strong synergistic effect between bimetals.

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