Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Phase I trial comparing bile acid and short-chain fatty acid alterations in stool collected from human subjects treated with omadacycline or vancomycin.
Antimicrob Agents Chemother
January 2025
Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
Unlabelled: Omadacycline, an aminomethylcycline tetracycline, has a low propensity to cause infection (CDI) in clinical trials. Omadacycline exhibited a reduced bactericidal effect compared with vancomycin on key microorganisms implicated in bile acid homeostasis and short-chain fatty acids (SCFAs), key components of CDI pathogenesis. The purpose of this study was to assess bile acid and SCFA changes in stool samples from healthy volunteers given omadacycline or vancomycin.
View Article and Find Full Text PDFTherapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection.
J Antibiot (Tokyo)
December 2024
Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
A significant increase in multidrug-resistant Methicillin-resistant Staphylococcus aureus (MRSA) infections has made it crucial to explore new antimicrobial drugs and strategies. Emerging evidence suggests that the bile acid metabolite isoallolithocholic acid (isoallo-LCA) may contribute to reducing the risk of infection among centenarians. However, its precise role remains somewhat ambiguous and necessitates further investigation.
View Article and Find Full Text PDFMulti-omics profiling reveals the molecular mechanisms of HO-induced detrimental effects on Thamnaconus septentrionalis.
BMC Genomics
October 2024
Observation and Research Station of Bohai Strait Eco-Corridor, Ministry of Natural Resources, First Institute of Oceanography, Qingdao, 266061, China.
Background: Hydrogen peroxide (HO), a novel water treatment agent, can be used for disinfection, water quality adjustment, and disease prevention, while excessive HO can injure farm animals, even leading to death. Hydrogen peroxide is a recommended disinfectant and bactericide for treating gill diseases and vibriosis in the greenfin horse-faced filefish Thamnaconus septentrionalis. However, its cumulative effect, toxic molecular mechanism and relevant signal transduction/metabolic networks in marine fishes are largely unknown.
View Article and Find Full Text PDFDevelopment and Evaluation of Bioconverted Milk with Anti-Microbial Effect against Periodontal Pathogens and α-Glucosidase Inhibitory Activity.
Microorganisms
June 2024
Department of Oral Microbiology, College of Dentistry, Wonkwang University, Iksan 54538, Republic of Korea.
To decrease periodontal pathogens and increase the number of beneficial bacteria, probiotics and bioactive compounds made via microbial bioconversion are recently used. In addition, the interest regarding probiotics-mediated bioconversion with popular medicinal plants is increasing. , a type of wormwood, has recently been attention as a medicinal plant due to its various bioactive compounds.
View Article and Find Full Text PDFInterference of gastrointestinal barriers with antibiotic susceptibility of foodborne pathogens: an in vitro case study of ciprofloxacin and tetracycline against Salmonella enterica and Listeria monocytogenes.
Food Res Int
July 2024
BioTeC(+), Chemical and Biochemical Process Technology and Control, KU Leuven, Gent, Belgium. Electronic address:
Minimum inhibitory concentrations (MIC) assays are often questioned for their representativeness. Especially when foodborne pathogens are tested, it is of crucial importance to also consider parameters of the human digestive system. Hence, the current study aimed to assess the inhibitory capacity of two antibiotics, ciprofloxacin and tetracycline, against Salmonella enterica and Listeria monocytogenes, under representative environmental conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!