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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer.
Life (Basel)
January 2025
Laboratory of Animal Histology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iași, Carol I bvd. 20A, 700505 Iasi, Romania.
Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations and environmental stressors, on the one hand, and cancer cell structure, functioning, and behavior. Aberrant PTMs can be considered as enabling characteristics of cancer as long as they orchestrate all malignant modifications and variability in the proteome of cancer cells, cancer-associated cells, and tumor microenvironment (TME). On the other hand, PTMs of proteins can enhance anticancer mechanisms in the tumoral ecosystem or sustain the beneficial effects of oncologic therapies through degradation or inactivation of carcinogenic proteins or/and activation of tumor-suppressor proteins.
View Article and Find Full Text PDFThe Genetic Expression Difference of A2058 Cells Treated by Plasma Direct Exposure and Plasma-Treated Medium and the Appropriate Treatment Strategy.
Biomedicines
January 2025
Department of Mechanical Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
: Cold atmospheric plasma (CAP) has been demonstrated as an adjustable device to generate various combinations of short-lived reactive oxygen and nitrogen species (RONS) and as a promising appliance for cancer therapy. This study investigated the effects of direct and indirect treatments of Argon-based CAP to cancer cells (A2058, A549, U2OS and BCC) and fibroblasts (NIH3T3 and L929) on cell viability. We also aimed to understand whether plasma-generated RONS were involved in this process using genetic evidence.
View Article and Find Full Text PDFAutophagic flux-lipid droplet biogenesis cascade sustains mitochondrial fitness in colorectal cancer cells adapted to acidosis.
Cell Death Discov
January 2025
The Third Affiliated of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, Jiangsu, China.
Cancer development is associated with adaptation to various stressful conditions, such as extracellular acidosis. The adverse tumor microenvironment also selects for increased malignancy. Mitochondria are integral in stress sensing to allow for tumor cells to adapt to stressful conditions.
View Article and Find Full Text PDFStructural design and safety performance of a novel high-strength steel lightweight guardrail.
PLoS One
January 2025
Key Laboratory of Road and Traffic Engineering of Ministry of Education, Tongji University, Shanghai, China.
Highway guardrails are critical safety infrastructure along roadways, designed to redirect vehicles back into their lanes and facilitate a gradual deceleration to a complete stop. Traditional highway steel guardrails exhibit significant limitations, including inadequate energy absorption, susceptibility to corrosion, and an increased risk of vehicles leaving the roadway during severe collisions. Furthermore, the production and transportation of these guardrails contribute to substantial carbon emissions and environmental pollution.
View Article and Find Full Text PDFInjectable Biocompatible Zeolite Nanocrystals for Enhanced Tumor Oxygenation and MRI Imaging.
ACS Appl Mater Interfaces
January 2025
Université de Caen Normandie, ENSICAEN, CNRS, LCS, 14000 Caen, France.
Tumor hypoxia significantly limits the effectiveness of radiotherapy, as oxygen is crucial for producing cancer-killing reactive oxygen species. To address this, we synthesized nanosized faujasite (PBS-Na-FAU) zeolite crystals using clinical-grade phosphate-buffered saline (PBS) as the solvent, ensuring preserved crystallinity, microporous volume, and colloidal stability. The zeolite nanocrystals showed enhanced safety profiles and , and studies showed no apparent toxicity to animals.
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