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Development and characterization of new carnosine-loaded liposomal formulations.
J Liposome Res
October 2024
Department of Drug and Health Sciences, University of Catania, Catania, Italy.
Carnosine is an endogenous dipeptide characterized by a multimodal mechanism of action. However, its clinical potential is limited by serum and cytosolic carnosinases, which significantly reduce its bioavailability. Based on that, different research groups have worked on the development of new strategies able not only to prevent its rapid metabolization but also to improve its distribution and specific targeting.
View Article and Find Full Text PDFAn Improved Method and Device for Nucleic Acid Isolation Using a High-Salt Gel Electroelution Trap.
Anal Chem
October 2024
Department of Biochemistry, Sechenov First Moscow State Medical University, Trubetskaya Str. 8-2, Moscow 119991, Russian Federation.
The success of DNA analytical methods, including long-read sequencing, depends on the availability of high-quality, purified DNA. Previously, we developed a method and device for isolating high-molecular-weight (HMW) DNA for long-read sequencing using a high-salt gel electroelution trap. Here, we present an improved version of this method for purifying nucleic acids with high yield and purity from even the most challenging biological samples.
View Article and Find Full Text PDFIn Vivo Detection of Infections Using Radiolabeled Antibodies Specific for Bacterial Toxins.
Int J Biomed Imaging
April 2024
Unidad de Medicina y Cirugía Experimental, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, Spain.
Purpose: The Gram-positive bacterium is one of the leading causes of infection in humans. The lack of specific noninvasive techniques for diagnosis of staphylococcal infection together with the severity of its associated complications support the need for new specific and selective diagnostic tools. This work presents the successful synthesis of an immunotracer that targets the -toxin released by .
View Article and Find Full Text PDFAn eco-friendly separation-based framework for quantitative determination and purity testing of an antihypertensive ternary pharmaceutical formulation.
BMC Chem
March 2023
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, 11562, Egypt.
Designing new, verified methodologies with a focus on sustainability, analytical efficiency, simplicity, and the environment has become a major priority for pharmaceutical quality control units. In this way, sustainable and selective separation-based methodologies were designed and validated for the concurrent estimation of amiloride hydrochloride (AML), hydrochlorothiazide (HCT) and timolol maleate (TIM) in their fixed dose formulation (Moducren Tablets) along with hydrochlorothiazide potential impurities, salamide (DSA) and chlorothiazide (CT). The first method is a high performance thin layer chromatographic method (HPTLC-densitometry).
View Article and Find Full Text PDFHigh Performance (High Pressure) Layer Electrochromatography Separation Technique: Equipment and Preliminary Results.
Anal Chem
June 2022
Department of Physical Chemistry, Chair of Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4a Chodźki Str., 20-093 Lublin, Poland.
We present a new prototype device and propose a new analytical technique: high performance (high pressure) layer electrochromatography (HPLEC). The equipment provides a combination of overpressured layer chromatography (OPLC) and pressurized planar electrochromatography (PPEC), yet it still enables researchers to perform each of these analyses separately. In comparison to PPEC, HPLEC provides hydrodynamic flow of the mobile phase, irrespective of the voltage used and the mobile phase composition.
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