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Turning Waste into Treasure: Functionalized Biomass-Derived Carbon Dots for Superselective Visualization and Eradication of Gram-Positive Bacteria.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, 2 Southeast University Road, Nanjing, 211189, P. R. China.
Gram-positive bacteria pose significant threats to human health, necessitating the development of targeted bacterial detection and eradication strategies. Nevertheless, current approaches often suffer from poor targeting specificity. Herein, the study utilizes purple rice lixivium to synthesize biomass carbon dots (termed BCDs) with wheat germ agglutinin-like residues for precisely targeting Gram-positive bacteria.
View Article and Find Full Text PDFAnodized Ti6Al4V-ELI, electroplated with copper is bactericidal against Staphylococcus aureus and enhances macrophage phagocytosis.
J Mater Sci Mater Med
January 2025
Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Implants aim to restore skeletal dysfunction associated with ageing and trauma, yet infection and ineffective immune responses can lead to failure. This project characterized the microbiological and host cell responses to titanium alloy with or without electroplated metallic copper. Bacterial viability counting and scanning electron microscopy quantified and visualized the direct and indirect bactericidal effects of the Cu-electroplated titanium (Cu-Ep-Ti) against two different Staphylococcus aureus strains.
View Article and Find Full Text PDFSelf-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for Infection Treatment.
Gels
January 2025
Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
, a prevalent zoonotic pathogen, poses a significant threat to skin wound infections. This study evaluates the bactericidal efficacy of self-assembled peptide hydrogels, PPI45 and PPI47, derived from the defensin-derived peptide PPI42, against ATCC43300. The high-level preparation of PPI45 and PPI47 was achieved with yields of 1.
View Article and Find Full Text PDFChemical composition, and activity of the methanolic extract derived from against clinically relevant bacteria.
J Toxicol Environ Health A
January 2025
Department of Morphology, Federal University of Santa Maria, Santa Maria, Brazil.
This study aimed to identify chemical compounds derived from Vassobia breviflora methanolic extract using ESI-ToF-MS and their antioxidant potential activity utilizing the following methods: total phenols, DPPH, and ABTS. The MTT assay measured cytotoxic activity, while DCFH-DA and nitric oxide assays were employed to determine reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels using African green monkey kidney (VERO) and human keratinocyte (HaCat) cell lines. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were assessed in seven clinical isolates and nine ATCC strains.
View Article and Find Full Text PDFParametric optimization, Polyphenol profiling and Bioefficacy of Bacopa monnieri (L.) Pennell phytoextract against multi-drug resistant (MDR) foodborne bacterial pathogens.
Microb Pathog
January 2025
Uttarakhand State Council for Science and Technology (UCOST), Vigyan Dham, Jhajra, Dehradun, India 248007.
Nowadays, antimicrobial resistance and foodborne burden are a prevalent global concern for human health and sustainable development. In this context, this study aimed to investigate the effect of Bacopa monnieri (L.) Pennell extract against pathogenic foodborne bacteria (Escherichia coli, Staphylococcus aureus, and Listeria monocytogenes).
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