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Induction of ermSV by 16-membered-ring macrolide antibiotics.
Antimicrob Agents Chemother
March 1997
Pharmacology Department, University of Wisconsin Medical School, Madison 53706, USA.
The erm family of 23S rRNA adenine-N6-methyltransferases confers resistance to all macrolide-lincosamide-streptograminB (MLS) antibiotics, but not all MLS antibiotics induce synthesis of Erm methyltransferase with equal efficiency in a given organism. The induction efficiency of a test panel of MLS antibiotics was studied by using two translational attenuator-lac reporter gene fusion constructs, one based on ermSV from Streptomyces viridochromogenes NRRL 2860 and the other based on ermC from Staphylococcus aureus RN2442. Four types of responses which were correlated with the macrolide ring size were seen, as follows: group 1, both ermSV and ermC were induced by the 14-membered-ring macrolides erythromycin, lankamycin, and matromycin, as well as by the lincosamide celesticetin; group 2, neither ermSV nor ermC was induced by the 12-membered-ring macrolide methymycin or by the lincosamide lincomycin or the streptogramin type B antibiotic ostreogrycin B; group 3, ermSV was selectively induced over ermC by the 16-membered-ring macrolides carbomycin, chalcomycin, cirramycin, kitasamycin, maridomycin, and tylosin; and group 4, ermC was selectively induced over ermSV by the 14-membered-ring macrolide megalomicin.
View Article and Find Full Text PDFMicrobial transformation of maridomycin III by Serratia marcescens.
J Antibiot (Tokyo)
December 1983
Two transformation products of maridomycin (MDM) III, MDM-S1 and MDM-S2 named after Serratia marcescens, were isolated by silica gel chromatography. NMR and IR analysis revealed that MDM-S1 and -S2 had no aldehyde group at C-18 on the macrolactone ring, and that the hydroxyl group at C-9 seemed to disappear. Although MDM-S1 and -S2 are less active against Gram-positive bacteria than starting MDM III they are interesting materials in view of the introduction of nitrogen into each molecule, and that the transformation products are produced by Gram-negative bacteria which are thought to be insensitive to macrolide antibiotics.
View Article and Find Full Text PDFInducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics in Streptomyces spp. comprises a family of diverse phenotypes in which characteristic subsets of the macrolide-lincosamide-streptogramin antibiotics induce resistance mediated by mono- or dimethylation of adenine, or both, in 23S ribosomal ribonucleic acid. In these studies, diverse patterns of induction specificity in Streptomyces and associated ribosomal ribonucleic acid changes are described.
View Article and Find Full Text PDFPriopionyl derivatives of maridomycins, 9-propionylmaridomycins (PMDMs), are sixteen-membered ring macrolide antibiotics of six analogous components: I, II, III, IV, V and VI. The present paper deals with the separation and quantitative analysis of these components. The analysis was performed by thin-layer chromatographic separation, addition reaction of gaseous iodine with PMDMs on the plate, extraction of the PMDM-iodine complexes, and subsequent analysis of the amount of reacted iodine, using an automatic analysis system.
View Article and Find Full Text PDFMaridomycins and their acyl derivatives (9-propionyl, 2'-propionyl and 9,2'-dipropionyl maridomycins) were separated quantitatively into six components by high-performance liquid chromatography using a Corasil I column (200 cm X 2 mm I.D.) with a mixed sovent (upper layer of n-hexane, diisopropyl ether, ethanol and water) as the eluent.
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