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Distinct dynamic regulation of pectoralis muscle metabolomics by insulin and the promotion of glucose-lipid metabolism with extended duration.
Poult Sci
December 2024
College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan 450046, China. Electronic address:
Birds' glycolipid metabolism has garnered considerable attention due to their fasting blood glucose levels being nearly twice those of mammals. While skeletal muscle is the primary insulin-sensitive tissue in mammals, the effects of insulin on chicken skeletal muscle remain unclear. In this study, the insulin-responsive metabolites were identified in broiler's pectoralis muscle (after 16 h of fasting) using widely targeted metabolomics.
View Article and Find Full Text PDFHigh-resolution Molecular Dynamics Simulations of the Pyruvate Kinase Muscle Isoform 1 and 2 (PKM1/2).
Chemistry
November 2024
Sorbonne Université - Campus Pierre et Marie Curie, Laboratoire de Chimie Théorique, 4 place Jussieu, 75005, Paris, FRANCE.
Glucose metabolism plays a pivotal role in physiological processes and cancer growth. The final stage of glycolysis, converting phosphoenolpyruvate (PEP) into pyruvate, is catalyzed by the pyruvate kinase (PK) enzyme. Whereas PKM1 is mainly expressed in cells with high energy requirements, PKM2 is preferentially expressed in proliferating cells, including tumor cells.
View Article and Find Full Text PDFHM-Chromanone Alleviates Hyperglycemia by Activating AMPK and PI3K/AKT Pathways in Mice Fed a High-Fat Diet.
Nutrients
November 2024
Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University, Busan 46241, Republic of Korea.
Objectives: We investigated potential antihyperglycemic effects of HM-chromanone (HMC), a homoisoflavonoid isolated from , in mice fed a high-fat diet (HFD).
Methods: Five-week-old male C57BL/6J mice ( = 24) were divided into three groups: controls, mice fed an HFD (11 weeks), and HFD-fed mice receiving HMC supplementation (8 weeks). Various analyses assessed liver and skeletal muscle proteins, pancreatic β-cell histology, blood glucose and HbA1c levels, and homeostatic index of insulin resistance (HOMA-IR).
Antidiabetic and Antihyperlipidemic Activities and Molecular Mechanisms of L. Extract in Mice on a High-Fat Diet.
Curr Issues Mol Biol
September 2024
Department of Nursing, College of Nursing, Central Taiwan University of Science and Technology, No. 666 Buzih Road, Beitun District, Taichung City 40601, Taiwan.
We planned to explore the protective activities of extract of L. (EPE) on insulin resistance and metabolic disorders including hyperlipidemia, visceral obesity, and renal dysfunction in high-fat diet (HFD)-progressed T2DM mice. Mice treatments included 7 weeks of HFD induction followed by EPE, fenofibrate (Feno), or metformin (Metf) treatment daily for another 4-week HFD in HFD-fed mice.
View Article and Find Full Text PDFSilencing of mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission.
Acta Biochim Biophys Sin (Shanghai)
September 2024
Department of Cardiology, the General Hospital of Western Theater Command, Chengdu 610083, China.
The pathological proliferation and migration of vascular smooth muscle cells (VSMCs) are key processes during vascular neointimal hyperplasia (NIH) and restenosis. Phosphoenolpyruvate carboxy kinase 1 (PCK1) is closely related to a variety of malignant proliferative diseases. However, the role of PCK1 in VSMCs has rarely been investigated.
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