Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups.
Mol Pharm
January 2025
Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Nanobodies, or single-domain antibody fragments, are promising candidates for molecular imaging due to their small size, rapid tissue penetration, and high target specificity. However, a significant challenge in their use is high renal uptake and retention, which can limit the therapeutic efficacy and complicate image interpretation. This study compares five different fluorine-18-labeled prosthetic groups for nanobodies, aiming to optimize pharmacokinetics and minimize kidney retention while maintaining tumor targeting.
View Article and Find Full Text PDFDevelopment of a Novel Prosthetic Click-Linker for Radioiodination of Antibody-Based Radiopharmaceuticals with High Stability and Specificity.
Mol Pharm
January 2025
Division of Applied RI, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea.
Article Synopsis
- Radioiodine is used in nuclear medicine for diagnosing and treating diseases, primarily through two methods of radioiodination: direct and indirect.
- The newly developed compound 3-[I]IBTTT offers a high radiochemical yield and purity while simplifying purification processes, overcoming issues present in traditional methods.
- This compound demonstrated effective HER2-specific binding in tumor imaging with minimal thyroid uptake, making it a promising option for targeting HER2-positive cancers.
A Brief Review of Radiolabelling Nucleic Acid-Based Molecules for Tracking and Monitoring.
J Labelled Comp Radiopharm
November 2024
Department of Life Sciences, University of Bath, Bath, UK.
The rise of nucleic acid-based therapeutics continues apace. At the same time, the need for radiolabelled oligonucleotides for determination of spatial distribution is increasing. Complex molecular structures with mostly multiple charges and low solubility in organic solvents increase the challenge of integrating radionuclides.
View Article and Find Full Text PDFDirect measurement of indoor thoron and radon progeny and estimation of inhalation dose in three cities in Gabon: Comparison of the use of thoron typical and measured equilibrium factor values.
J Environ Radioact
December 2024
Institute of Radiation Emergency Medicine, Hirosaki University, Japan.
Article Synopsis
- This study examines radon and thoron exposure in homes in Franceville, Moanda, and Mounana, Gabon, focusing on measuring the equilibrium factor between thoron and its progeny for better estimation of health risks.
- Researchers deployed 150 detectors over three months, finding average thoron progeny concentrations of about 1.54 to 3.05 Bq/m3 across the towns, with varying equilibrium factor values indicating significant differences from established standards.
- The results suggest that the estimated annual effective inhalation doses in these locations are notably higher than previously calculated values from the UNSCEAR report, indicating potential health risks from natural radioactivity in these areas.
Preliminary Research of Radiolabeled Atezolizumab for the Noninvasive Evaluation of TNBC PD-L1 Expression In Vivo.
J Labelled Comp Radiopharm
September 2024
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Article Synopsis
- PD-L1 expression is linked to how well triple-negative breast cancer treatments work and patient outcomes.
- The study synthesized a new imaging agent, [I]PI-Atezolizumab, which showed stability in lab settings and maintained effective binding to PD-L1 without losing its affinity.
- Animal studies demonstrated that [I]PI-Atezolizumab has better stability and targeted imaging capabilities for PD-L1, proving useful for monitoring in triple-negative breast cancer models.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!