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Investigation of Genetic Polymorphisms Related GSTM1, GSTT1, GSTP1 Genes and their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients.
Asian Pac J Cancer Prev
January 2025
Department of Molecular Biology & Genetics, Krishna Institute of Allied Sciences, Krishna Vishwa Vidyapeeth "Deemed to be University", Taluka-Karad, Dist- Satara, Pin-415 539, (Maharashtra) India.
Background: In this study we explored the association of polymorphisms of glutathione s transferase gene including GSTM1, GSTT1 and GSTP1 with adverse acute normal tissue reactions resulted from radiotherapy in HNC patients. We assessed the association of GSTM1 and GSTT1 null genotypes and Ile105Val of exon-5 and Ala114Val of exon-6 of GSTP1 gene polymorphisms with the risk of acute skin toxicity reactions after therapeutic radiotherapy in HNC patients.
Methods: Four hundred HNC patients administered with Intensity modulated radiation therapy were enrolled in this study for the evaluation of radiotherapy associated toxicity reactions.
Systematic Review of Patient Preference Studies in Non-metastatic Breast Cancer Adjuvant Medication Therapy: Attribute Selection.
Iran J Pharm Res
June 2024
Department of Pharmacoeconomics and Pharmaceutical Administration, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Context: Breast cancer poses significant challenges due to its high incidence and prevalence, necessitating heightened attention. Understanding how patients prioritize different treatment options based on various attributes can assist healthcare decision-makers in maximizing patient utility. The discrete choice experiment, a conjoint method, facilitates preference elicitation by presenting different attributes and choices.
View Article and Find Full Text PDFSelf-amplifying RNA virus vectors for drug delivery.
Expert Opin Drug Deliv
January 2025
Research & Development, PanTherapeutics, Lutry, Switzerland.
Article Synopsis
- Self-amplifying RNA viruses are effective tools for delivering genetic information and enhancing antigen production against infectious diseases and cancers by amplifying RNA within host cells.
- Extensive research, including animal studies and clinical trials, has shown that these viral vectors can generate significant immune responses, with potential applications in treating tumors and protecting against pathogens.
- The promising results from preclinical studies have led to the approval of a vaccine using a self-amplifying RNA virus for Ebola, indicating their potential in therapeutic interventions and future research in areas like neurological disorders.
Purpose: To establish the potential prognostic nutritional index (PNI) trajectory categories and examine the association between these PNI trajectory categories and severe radiotherapy-induced oral mucositis (RIOM).
Materials And Methods: This was a longitudinal retrospective observational study on 470 head and neck cancer inpatients who were to undergo radiotherapy from a grade-A tertiary hospital in Hunan Province between July 2022 and October 2023. The latent class growth model and growth mixed model were used to identify PNI trajectory categories.
Photodynamic therapy for oral mucositis in cancer patients- a systematic review and meta-analysis.
Photodiagnosis Photodyn Ther
December 2024
Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Department of Oral Diseases, Karolinska Institutet, Huddinge, Sweden.
Aim: This systematic review aimed to evaluate the efficacy of photodynamic therapy (PDT) in reducing the severity of chemotherapy-induced oral mucositis, and associated symptoms in cancer patients compared to standard care or other interventions.
Materials And Methods: A comprehensive literature search identified seven relevant studies (randomized controlled trials and non-randomized clinical trials) published between January 1, 2000, and May 31, 2024. The data analysis was carried out using the standardized mean difference as the outcome measure.
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