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Approach to Endocrine Hypertension: A Case-Based Discussion.
Curr Hypertens Rep
January 2025
Department of Endocrinology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, India.
Purpose Of Review: Hypertension remains a major chronic disease morbidity across the world, even in the twenty-first century, affecting ≈40% of the global population, adversely impacting the healthcare budgets in managing the high incidence of cardiovascular disease (CVD) complications and mortality because of elevated blood pressure (BP). However, evaluation and management of endocrine hypertension are not optimal in clinical practice. With three unique clinical case scenarios, we update the evidence base for diagnostic evaluation and management of endocrine hypertension in this review to inform appropriate day-to-day clinical practice decisions.
View Article and Find Full Text PDFCase report: Pheochromocytoma-induced pseudo-Cushing's syndrome.
Front Endocrinol (Lausanne)
January 2025
Department of Internal Medicine and Endocrinology, University Clinical Centre of the Medical University of Warsaw, Warsaw, Poland.
Article Synopsis
- Non-neoplastic hypercortisolaemia, or pseudo-Cushing's syndrome (PCS), can occur due to various health conditions like depression, obesity, and diabetes, linked to overactivity of the hypothalamic-pituitary-adrenal axis.
- A 66-year-old woman exhibited symptoms such as weakness, weight loss, and poorly controlled hypertension, which led to the discovery of pheochromocytoma, a tumor that causes hormone overproduction, upon further testing.
- After undergoing surgery to remove the tumor and receiving supportive treatment, her symptoms improved significantly, confirming the diagnosis of PCS rather than traditional Cushing's syndrome.
The role of methylation quantification of circulating tumor DNA (ctDNA) as a diagnostic biomarker of Pheochromocytomas (PCCs) and Paragangliomas (PGLs).
J Diabetes Metab Disord
December 2024
Urology Research Center, Tehran University of Medical Sciences, Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave, Tehran, Iran.
Objectives: Circulating tumor DNAs (ctDNAs) are fragments of malignant tissue DNA that can simply signify the real time genetic change and epigenetic modification of a solid tumor tissue. Pheochromocytomas (PCCs) and Paragangliomas (PGLs) are malinancy of adrenal gland tissue that have the possible diagnosis by ctDNAs. In this study the methylation quanifcation of three target genes , , and in the ctDNA of PCCs/PGLs patients were measured as a diagnostic biomarker.
View Article and Find Full Text PDFArticle Synopsis
- Hypoglycemia can occur after pheochromocytoma surgery due to reduced catecholamine levels, with dialysis patients possibly experiencing unique challenges.
- A 47-year-old woman with chronic renal failure and pheochromocytoma had surgery and faced significant hypoglycemia, needing continuous glucose infusion for eight days post-operation.
- Hemodialysis patients may require more vigilant monitoring and management of hypoglycemia after such surgeries compared to those without dialysis.
Unveiling Pheochromocytoma: A Puzzling Prelude of Nausea, Vomiting, and Abdominal Pain.
Am J Case Rep
September 2024
Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Article Synopsis
- Pheochromocytomas are rare adrenal tumors that can cause various symptoms, potentially leading to misdiagnosis and serious complications, such as hypertensive crises and cardiovascular damage from chronic high blood pressure.
- A case of a 45-year-old woman with gastrointestinal symptoms was found to be related to a pheochromocytoma, confirmed through biochemical testing before undergoing any procedures that could provoke dangerous surges of catecholamines.
- The patient's symptoms resolved after surgical removal of the tumor, illustrating the importance of screening for pheochromocytoma in individuals presenting with non-specific symptoms that might impact surrounding organs.
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