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Extreme hypernatremia after a laparoscopic hysterectomy and bilateral salpingo-oophorectomy: a case report and literature review.
Front Surg
October 2024
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- * A case study details an unusual instance of NDI in a 50-year-old Chinese woman who developed symptoms after cervical cancer surgery, leading to a diagnosis through various tests and genetic analysis revealing a specific mutation.
- * The patient improved significantly after a low-sodium diet and medication, highlighting the necessity of specialized tests to accurately diagnose and manage NDI, even in older females, where it's less common.
Involvement of Cholinergic and Cyclooxygenase Pathways in the Diuretic Effects of Rosmarinic Acid.
Chem Biodivers
October 2024
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, 88302-901 -, Itajaí, Santa Catarina, Brasil.
Rosmarinic acid (RA) is a natural antioxidant known for its diverse biological activities. Although its diuretic activity has been previously established, the mode of action remained unclear. To investigate this, we examined the diuretic activity of RA alone and in combination with hydrochlorothiazide (HCTZ), amiloride (AML), atropine (ATR), and indomethacin (INDO) to see if any of these drugs could interfere with RA's activity in an 8 hour acute diuresis animal model.
View Article and Find Full Text PDFHighly sensitive voltammetric determination of hydrochlorothiazide using a glassy carbon electrode modified with Super P carbon black nanoparticles.
Anal Methods
September 2024
Department of Chemical Technology, Federal University of Maranhão, 65080-805, São Luís, Maranhão, Brazil.
Hydrochlorothiazide is an extremely important diuretic that regulates body functions, which can prevent several diseases. However, the abuse of this diuretic is concerning since it does not require a medical prescription, particularly for aesthetic purposes such as weight loss, which can lead to various health problems, including ventricular arrhythmia. The present work aims to use a glassy carbon electrode modified with Super P carbon black (SPCB/GCE) to quantify hydrochlorothiazide through Linear Sweep Adsorptive Stripping Voltammetry (LSAdSV).
View Article and Find Full Text PDFA novel gene mutation in a Chinese pedigree with nephrogenic diabetes insipidus.
Postgrad Med
August 2024
The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Nephrogenic diabetes insipidus (NDI) is a rare genetic disorder primarily associated with mutations in the arginine vasopressin receptor 2 () gene or the aquaporin 2 () gene, resulting in impaired water reabsorption in the renal tubules. This report describes a case of a young male patient with NDI from China with a history of polydipsia and polyuria for over 15 years. Laboratory examinations of the proband indicated low urine-specific gravity and osmolality.
View Article and Find Full Text PDFAmiloride versus furosemide for the treatment of edema in patients with nephrotic syndrome: A pilot study (AMILOR).
Acta Physiol (Oxf)
August 2024
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.
Aim: In rodent models of nephrotic syndrome (NS), edema formation was prevented by blockade of the epithelial sodium channel ENaC with amiloride. However, apart from case reports, there is no evidence favoring ENaC blockade in patients with NS.
Methods: The monocentric randomized controlled AMILOR study investigated the antiedematous effect of amiloride (starting dose 5 mg/day, max.
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