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Interrupted borrowing hydrogen strategy enabled aminomethylation and direct cross-dehydrogenative coupling strategy enabled dicarbonylation reactions of imidazo[1,5-]pyridines.
Chem Commun (Camb)
January 2025
Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu & Kashmir, 180001, India.
Herein, we disclose the development of novel aminomethylation and dicarbonylation reactions of imidazo[1,5-]pyridines. The developed aminomethylation strategy involves a Pd-catalyzed interrupted borrowing hydrogen strategy by utilizing MeOH as the methylene source. A wide variety of imidazo[1,5-]pyridines and secondary amines were explored for the developed strategy.
View Article and Find Full Text PDFGlufosinate (GLUF) and glyphosate (GLY) are nonselective phosphorus-containing amino acid herbicides that are widely used in agricultural gardens and noncultivated areas. These herbicides give rise to a number of key metabolites, with 3-methyl phosphinicopropionic acid (MPPA), -acetyl glufosinate (-acetyl GLUF), aminomethyl phosphonic acid (AMPA), -acetyl aminomethyl phosphonic acid (-acetyl AMPA), -acetyl glyphosate (-acetyl GLY), -methyl glyphosate (-methyl GLY) as the major metabolites obtained from GLUF and GLY. Extensive use of these herbicides may lead to their increased presence in the environment, especially aquatic ecosystems.
View Article and Find Full Text PDFDifferences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers.
Toxicol Mech Methods
January 2025
Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.
The rat S9 microsome fraction is commonly used to assess compound metabolite formation during genotoxicity assessments. However, methods using S9 have not been standardized for genotoxicity studies, and different experimental methods are used at various facilities. Therefore, this study investigated whether the differences between the two experimental conditions (1) S9 inducers, phenobarbital + beta-naphthoflavones vs.
View Article and Find Full Text PDFElectro-catalyzed, solvent-controlled divergent decarboxylative annulation and hydroaminomethylation of cyclic aldimines with -arylglycines.
Chem Commun (Camb)
January 2025
Department of Chemistry & Chemical Engineering, Gannan Normal University, Ganzhou 341000, China.
Herein, we reported a sustainable and simple method involving electrochemical-catalyzed decarboxylative annulation and hydroaminomethylation of cyclic aldimines with -arylglycines by switching the reaction solvents. When the reaction was carried out in MeCN/HO or HO, the resulting products included imidazolidine-fused sulfamidates and C4-aminomethylated cyclic aldimines, obtained in moderate to good yields, respectively. Mechanistically, a radical pathway was proposed to be involved in this approach.
View Article and Find Full Text PDF1.4% External Quantum Efficiency 988 nm Light Emitting Diode Based on Tin-Lead Halide Perovskite.
Adv Mater
December 2024
Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 3, Groningen, 9747 AG, The Netherlands.
In recent years, metal halide perovskite-based light-emitting diodes (LEDs) have garnered significant attention as they display high quantum efficiency, good spectral tunability, and are expected to have low processing costs. When the peak emission wavelength is beyond 900 nm the interest is even higher because of the critical importance of this wavelength for biomedical imaging, night vision, and sensing. However, many challenges persist in fabricating these high-performance NIR LEDs, particularly for wavelengths above 950 nm, which appear to be limited by low radiance and poor stability.
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