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Host response to cholestyramine can be mediated by the gut microbiota.
Microbiome Res Rep
July 2024
Department of Biomedical Sciences, Carson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
The gut microbiota has been implicated as a major factor contributing to metabolic diseases and the response to drugs used for the treatment of such diseases. In this study, we tested the effect of cholestyramine, a bile acid sequestrant that reduces blood cholesterol, on the murine gut microbiota and metabolism. We also explored the hypothesis that some effects of this drug on systemic metabolism can be attributed to alterations in the gut microbiota.
View Article and Find Full Text PDFManagement of perioperative thyrotoxicosis - what to do when standard therapy is contraindicated or fails?
Front Endocrinol (Lausanne)
December 2024
Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
Background: Current guidelines recommend that hyperthyroid patients should be rendered euthyroid prior to surgical procedures. These guidelines rely heavily on the use of ATDs as the primary medication, and do not give recommendations for patients who have contraindications to ATDs, or for whom standalone ATD treatment is inadequate.
Objectives: To evaluate the efficacy and safety of adjunctive pharmacological therapy and/or therapeutic plasma exchange (TPE) in the perioperative management of patients with thyrotoxicosis who were intolerant to ATD or for whom standalone ATD therapy was inadequate to achieve euthyroidism prior to surgery.
Influence of gut bile acid composition on the glucose-lowering effect and safety of metformin.
Br J Clin Pharmacol
December 2024
Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Republic of Korea.
Article Synopsis
- The study investigates how cholestyramine, a bile acid sequestrant, influences the effectiveness of metformin in lowering blood glucose levels by altering intestinal bile acid composition.
- It involved healthy male adults in a two-period crossover design, where participants received metformin alone in the first period and with cholestyramine in the second, measuring various glucose response parameters.
- Results showed that cholestyramine further decreased the glucose-lowering effects of metformin and improved the associated side effect of diarrhea in some participants.
Sepiolite-Chitosan-Acetic Acid Biocomposite Attenuates the Development of Obesity and Nonalcoholic Fatty Liver Disease in Mice Fed a High-Fat Diet.
Nutrients
November 2024
Laboratory of Integrative Physiology, The Department of Nutrition and Natural Products, MIGAL-Galilee Research Institute, P.O. Box 831, Kiryat Shmona 11016, Israel.
Background; obesity and nonalcoholic fatty liver disease (NAFLD) reduce life expectancy; nonoperative interventions show poor results. Individually, chitosan (1% /), acetic acid (AA 0.3-6.
View Article and Find Full Text PDFPrevalence and Pathophysiology of Loose Stools and Their Impact on Clinical Severity and Quality of Life in Women With Fecal Incontinence.
J Clin Gastroenterol
October 2024
Gastrointestinal Motility Unit, Mataró Hospital, Consorci Sanitari del Maresme, Mataró, Catalonia.
Objective: To compare the impact of fecal consistency with anorectal sphincter dysfunctions on clinical severity and quality of life (QoL) in women with fecal incontinence (FI).
Background: FI affects up to 24% of middle-aged women, significantly impacting their QoL. Pathophysiological studies have focused more on sphincter and anorectal dysfunctions than on the role of fecal consistency.
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