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Acute Surgical and Rehabilitation Management of Complex Hand Burns in Combat Casualties.
Eur Burn J
May 2024
U.S. Army Institute of Surgical Research Burn Center, 3698 Chambers Pass, JBSA, Fort Sam Houston, TX 78234, USA.
Article Synopsis
- Burns account for 5% to 20% of injuries in modern warfare, with hand injuries being the most common cause of long-term functional impairment.
- This paper aims to guide the management of complex hand burns in battlefield settings by emphasizing the importance of early assessment and care plans.
- Key treatment strategies include managing swelling, providing quick wound coverage, performing necessary surgical procedures, starting aggressive hand therapy early, and preventing burn-related contractures.
Evidence Supporting Conservative Scar Management Interventions Following Burn Injury: a review article.
J Burn Care Res
November 2024
School of Physical and Occupational Therapy, McGill University, Montréal, Québec, Canada.
Conservative management for hypertrophic scars (HSc) and scar contractures is of utmost importance to optimally reintegrate burn survivors into society. Many conservative treatment interventions have been described in the literature for the management of HSc. Recent advancements in the literature pertaining to post-burn scarring and HSc formation, have advanced our understanding of the mechanisms that support or refute the use of common rehabilitation treatment modalities after burn injury.
View Article and Find Full Text PDFMolecular mechanisms of post-burn muscle wasting and the therapeutic potential of physical exercise.
J Cachexia Sarcopenia Muscle
April 2023
Department of Rehabilitation Sciences & Physiotherapy, Research group MOVANT, Multidisciplinary Metabolic Research Unit (M2RUN), University of Antwerp, Antwerp, Belgium.
After a severe burn injury, a systemic stress response activates metabolic and inflammatory derangements that, among other, leads to muscle mass loss (muscle wasting). These negative effects on skeletal muscle continue for several months or years and are aggravated by short-term and long-term disuse. The dynamic balance between muscle protein synthesis and muscle protein breakdown (proteolysis) is regulated by complex signalling pathways that leads to an overall negative protein balance in skeletal muscle after a burn injury.
View Article and Find Full Text PDFHistone deacetylase inhibitor attenuates intestinal mucosal injury in fatally scalded rats.
Ann Transl Med
January 2022
Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Background: Severe burns, trauma and shock can cause intestinal epithelial barrier dysfunction, which can lead to intestinal endotoxemia and even sepsis and multi-organ dysfunction. Many studies have shown that histone deacetylase inhibitors (HDACIs) can improve cell tolerance to hypoxia and inflammation, thus protecting the functions of important organs in the body, and at the same time, inhibiting the degradation of tight junction (TJ) proteins, protecting the intercellular barrier, and reducing tissue edema and organ damage. However, the mechanism is unclear.
View Article and Find Full Text PDFA narrative review of changes in microvascular permeability after burn.
Ann Transl Med
April 2021
Burn Institute, The Fourth Medical Center of the PLA General Hospital, Beijing, China.
Objective: We aimed to review and discuss some of the latest research results related to post-burn pathophysiological changes and provide some clues for future study.
Background: Burns are one of the most common and serious traumas and consist of a series of pathophysiological changes of thermal injury. Accompanied by thermal damage to skin and soft tissues, inflammatory mediators are released in large quantities.
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