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[Characteristics of the thermoregulatory reactions of mice and rats to mediator-active substances].
Zh Evol Biokhim Fiziol
January 1983
The effect of dopaminomimetics (apomorphine, piribedil, bromocriptine), cholinomimetics (oxotremorine, arecoline, pylocarpine), and neuroleptics (chlorpromazine, haloperidol, triperidol) on rectal temperature (Tr) and temperature of different parts of the skin has been investigated in albino mice and rats of either sex. In rats these drugs cause the decrease of Tr and significantly increase tail temperature (Tt), as well as the temperature of the fore- and hindpaws (Tfp and Thp correspondingly). In mice the drug-induced fall of Tr is more significant than in rats; however, only neuroleptics essentially increase Tfp and Thp, the increase in Tt being inconsistent and small.
View Article and Find Full Text PDFAtropine stereotypy and its inhibition by intracaudate triperidol in the rat.
Pol J Pharmacol Pharm
March 1980
One component (rearing) of the stereotyped behavior of the rat was quantitated using erigometer, a new device developed in this laboratory. Intraperitoneal injection of atropine, but not methylatropine, caused dose-related stereotyped behavior in the rat and this effect was antagonized by intracaudate injection of triperidol in a dose-related manner. It is concluded that stereotypy can be evoked also in the case when the striatal dopaminergic tone is normal or even below normal: it is the equilibrium of the striatal cholinergic-dopaminergic systems which must be shifted towards dopamine, which is necessary for the development of this behavioral manifestation.
View Article and Find Full Text PDFPsychotropic drugs as potential antitumor agents: a selective screening study.
Cancer Treat Rep
January 1978
Compounds with known psychotropic properties were tested for activity in murine ip L1210 leukemia and B 16 melanoma in a protocol designed to obtain leads for new antitumor agents which might also possess central nervous system (CNS) antitumor properties. Barbiturates and hallucinogenic compounds were the only compound types deliberately excluded. Representatives from most of the other known CNS agent classes were included among the 297 psychotropic drugs evaluated.
View Article and Find Full Text PDFTriperidol was found to be a more potent 3H-dopamine uptake inhibitor than chlorpromazine in homogenates from rat striatum. Inhibition kinetics were competitive for triperidol and non-competitive for chlorpromazine. When drugs were given in vivo, d-amphetamine (10 mg/kg) blocked the 3H-dopamine uptake by about 50% whereas the neuroleptics did not modify the process even at highly sedating doses.
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