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Neoplastic premalignant pancreatobiliary lesions: current update on the spectrum of lesions and their imaging appearances.
Abdom Radiol (NY)
January 2025
The University of Texas MD Anderson Cancer Center, Houston, USA.
Common pancreatobiliary epithelial malignancies such as pancreatic ductal adenocarcinoma, cholangiocarcinoma and gallbladder carcinoma have poor prognosis. A small but significant portion of these malignancies arise from mass-forming grossly and radiologically visible premalignant epithelial neoplasms in the pancreatobiliary tree. Several lesions, including a few recently described entities, fall under this category and predominantly include papillary epithelial lesions with or without mucin production.
View Article and Find Full Text PDFPrognostic Significance of Tumor Budding in Ampullary Carcinomas.
Int J Surg Pathol
January 2025
Department of Pathology, Marmara University School of Medicine, Pendik/Istanbul, Turkey.
The presence of high tumor budding in colorectal carcinomas is a significant pathological feature indicative of a high potential for lymph node metastasis. Our aim was to investigate the prognostic impact of tumor budding in ampullary carcinomas. We conducted a cohort of 101 consecutive ampullary carcinoma resections to evaluate tumor budding, macroscopic and microscopic subtypes, lymphatic/vascular/perineural invasions, and other histopathological parameters.
View Article and Find Full Text PDFROBOTIC PANCREATICODUODENECTOMY FOR THE TREATMENT OF A MIXED NEUROENDOCRINE-NON-NEUROENDOCRINE NEOPLASM (MINEN) OF THE AMPULLA OF VATER.
Arq Bras Cir Dig
December 2024
Hospital Moriah, Endoscopy Department - São Paulo (SP), Brazil.
Mixed neuroendocrine-non-neuroendocrine tumors (MiNEN) are a rare type of tumor formed by two components, a non-neuroendocrine component that is most often an adenocarcinoma and a neuroendocrine tumor, and each of these components must represent at least 30% of the tumor. The origin of this tumor on the ampulla of Vater or periampullary region is more infrequent. Usually, the lesions are highly aggressive and quickly metastasizing, and their biological behavior is dictated by the high grade of the neuroendocrine component.
View Article and Find Full Text PDFTransduodenal ampullectomy is an effective surgical exploration procedure for unexplained dilation of the cholangiopancreatic duct.
Eur J Med Res
November 2024
Department of Hepatobiliary and Pancreatic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 S. Yishan Road, Shanghai, 200233, China.
Article Synopsis
- The study investigates the challenges in diagnosing and treating unexplained dilation of the cholangiopancreatic duct (UDCD) and assesses the effectiveness of transduodenal ampullectomy (TDA) as a potential solution.
- A retrospective analysis of 203 patients (14 from the hospital and 189 from other studies) showed that TDA enhances the diagnostic capability compared to traditional methods, with a significantly higher rate of identifying issues during surgery (78.41% vs. 65.94%).
- The study concludes that TDA is a safe and effective option for diagnosing and treating UDCD, with varying survival rates based on the pathology found, and reports a complication rate of 27.07% but
Prognostic efficacy of lymph node parameters in resected ampullary adenocarcinoma based on long-term follow-up data after adjuvant treatment.
World J Surg Oncol
November 2024
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
Article Synopsis
- * Analyzed data from 86 patients showed that multiple LN metrics were linked to overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS), particularly highlighting the number of metastatic LNs (LNN) as a strong predictor in multivariable analysis.
- * Key findings included LNN ≥ 2 as a significant factor for OS, DFS, and DMFS, while lymph node ratio (LNR) was notable for DFS and DMFS; however, certain parameters like log odds of positive
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