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Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential.
Front Cell Neurosci
January 2025
Reserach Unit "Drosophila"UR22ES03, Faculty of Medicine, University of Sfax, Sfax, Tunisia.
Background: The human gut mycobiome, a minor but integral component of the gut microbiome, has emerged as a significant player in host homeostasis and disease development. While bacteria have traditionally been the focus of gut microbiome studies, recent evidence suggests that fungal communities (mycobiota) may also play a crucial role in modulating health, particularly in neuropsychiatric disorders.
Objective: This review aims to provide a comprehensive overview of current knowledge on the relationship between the gut mycobiome and neuropsychiatric disorders, exploring the potential of targeting fungal communities as a novel therapeutic strategy.
A Case Report: The Vicious Cycle of Schizophrenia, Substance Abuse, and Human Trafficking.
Cureus
December 2024
Psychiatry, LifeStream Behavioral Center, Leesburg, USA.
Patients with schizophrenia often find themselves in vulnerable situations because their cognitive impairments can make them more susceptible to exploitation and crime. A prevalent misconception is that schizophrenia is synonymous with violence, possibly fueled by selective media coverage that highlights instances of violent crimes involving individuals with schizophrenia. In reality, a large percentage of people with schizophrenia do not display violent behavior.
View Article and Find Full Text PDFDirect effects of antipsychotics on potassium channels.
Biochem Biophys Res Commun
January 2025
Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea. Electronic address:
Schizophrenia (SCZ) and bipolar disorder (BD) and are severe psychiatric conditions that contribute to disability and increased healthcare costs globally. Although first-, second-, and third-generation antipsychotics are available for treating BD and SCZ, most have various side effects unrelated to their unique functions. Many antipsychotics affect K channels (Kv, K, Kir, K, and other channels), which change the functions of various organs.
View Article and Find Full Text PDFKnowledge and Skills of Midwives Regarding Perinatal Mental Health and Their Needs for Further Education.
Cureus
December 2024
Department of Midwifery, University of West Attica, Athens, GRC.
Introduction The literature highlights the crucial role of midwives in assessing and managing perinatal mental health and in providing information to women about related issues. However, research also indicates significant gaps in midwives' knowledge and skills needed to fulfill this role. Data suggest that while midwives are interested in providing mental health support, they lack the confidence, knowledge, and training to do so effectively.
View Article and Find Full Text PDFShould we consider microbiota-based interventions as a novel therapeutic strategy for schizophrenia? A systematic review and meta-analysis.
Brain Behav Immun Health
February 2025
Oswaldo Cruz Foundation, Institute Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Schizophrenia is a chronic psychiatric disorder characterized by a variety of symptoms broadly categorized into positive, negative, and cognitive domains. Its etiology is multifactorial, involving a complex interplay of genetic, neurobiological, and environmental factors, and its neurobiology is associated with abnormalities in different neurotransmitter systems. Due to this multifactorial etiology and neurobiology, leading to a wide heterogeneity of symptoms and clinical presentations, current antipsychotic treatments face challenges, underscoring the need for novel therapeutic approaches.
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