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The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke.

Transl Vis Sci Technol

March 2025

Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Purpose: We aimed to analyze retinal neurovascular unit (RNVU) alterations and function via optical coherence tomography angiography (OCTA) and full-field electroretinography (ERG) in patients with ischemic stroke (IS).

Methods: OCTA was used to measure RNVU changes in 229 participants (101 with IS and 128 healthy controls). The RETeval device was used to record full-field electroretinograms (FERGs) in 40 participants (14 with IS and 26 healthy controls).

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Validity and reliability of the 6-min stepper test in hypertensive individuals.

J Hypertens

March 2025

Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Department of Cardiorespiratory Physiotherapy and Rehabilitation, Ankara, Turkey.

Background: Hypertension is a common public health problem characterized by high blood pressure (BP) and associated with complications such as coronary artery disease, stroke, and renal failure. Physical activity and exercise regulate BP, and assessment of exercise capacity is a cornerstone of exercise training.

Objective: The aims of this study were to evaluate the validity and reliability of the 6-min stepper test (6MST) in hypertensive individuals and compare their physiological responses during the 6MST and 6-min walk test (6MWT).

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Background: Limited research has explored the prognostic significance of changes in coronary flow velocity reserve (CFVR), as measured by stress-transthoracic Doppler echocardiography (S-TDE), following elective percutaneous coronary intervention (PCI). This study aimed to assess whether post-PCI changes in CFVR are associated with major adverse cardiac events (MACE) and to identify baseline clinical factors that predict improvement of CFVR.

Methods: A retrospective analysis was performed on 184 patients who underwent elective FFR-guided PCI for the left anterior descending (LAD) artery.

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Objective: Mixed lineage kinase domain-like protein (MLKL) is a key component of necroptosis. Here, serum MLKL levels were measured with the intent to assess its prognostic significance in acute intracerebral hemorrhage (ICH).

Methods: A collective of 161 patients with acute primary supratentorial ICH and 73 controls were enlisted in this multicenter prospective cohort study.

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