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Gestational arsenite exposure alters maternal postpartum heart size and induces Ca-handling dysregulation in cardiomyocytes.
Am J Physiol Heart Circ Physiol
January 2025
Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
Cardiovascular disease is the leading cause of mortality in the US. Studies suggest a role for environmental exposures in the etiology of cardiovascular disease, including exposure to arsenic through drinking water. Arsenic exposure during pregnancy has been shown to have effects on offspring, but few studies have examined impacts on maternal cardiovascular health.
View Article and Find Full Text PDFLeft Bundle Branch Pacing Impact on QRS Amplitude in Different Pacing Voltages.
J Cardiovasc Electrophysiol
January 2025
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Left bundle branch pacing (LBBP) emerged as a novel physiological pacing modality that improves clinical outcomes. This study aimed to explore the impact of LBBP on QRS wave amplitude (RWA).
Methods: This prospective observational study included patients with complete left bundle branch block (CLBBB) and cardiac resynchronization therapy (CRT) indication, as well as patients with QRSd < 120 ms and pacemaker indication.
Enhanced vascular contraction induced by exposure to angiotensin II mediated by endothelin-1 biosynthesis following PKCβ activation.
Am J Physiol Heart Circ Physiol
January 2025
Laboratory of Veterinary Pharmacology, Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Ehime, Japan.
Protein kinase C (PKC) reportedly plays a role in the pathogenesis of many vascular dysfunction-related conditions. In this study, we investigated whether PKCβ is associated with vascular contractile changes induced by angiotensin II (Ang II) exposure. Long-term (24 h) treatment of rat aortae and mesenteric arteries in Ang II-containing culture medium enhanced 5-hydroxytrypatamine (5-HT)-induced vascular contraction in a dose-dependent manner, in association with enhanced phosphorylation of PKCβ S660.
View Article and Find Full Text PDFVariations in Neuromuscular Functions After Platelet-Rich Plasma and Dextrose Injections in Chronic Lateral Epicondylitis: A Randomized Controlled Study.
Sports Health
January 2025
Institute of Allied Health Sciences, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
Background: Lateral epicondylitis is caused by overuse and manifests as pain, weakness, and difficulty with object manipulation. Platelet-rich plasma (PRP) and dextrose injections have shown promise in reducing pain and improving function.
Hypothesis: PRP is more effective for force precision control of the extensor carpi radialis brevis (ECRB) muscle than dextrose injection for patients with chronic lateral epicondylitis (CLE).
Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.
J Orthop Surg Res
January 2025
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.
Background: Knee Osteoarthritis (KOA) is a prevalent condition worldwide, significantly diminishing quality of life and productivity. Except for the alignment change, muscle activation patterns (MAP) have garnered increasing attention as another crucial factor contributing to KOA.
Objective: This study explores the factors, characteristics, and effects of MAP changes caused by KOA, providing a neuromuscular-based causal analysis for the rehabilitation treatment of KOA.
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