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Pharmacokinetics and metabolism of dimethophrine labelled with tritium have been investigated on 5 subjects treated orally with a single dose of 100 mg. The results obtained have shown that: 1. the absorption and urinary elimination are rather slow; 2.
View Article and Find Full Text PDFThe serum kinetics and urinary metabolism of an a-sympathomimetic amine 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-monomethyl-amino-ethanol (dimethophrine) were studied. For serum kinetics, seven groups of 6 rats were sacrificed at 0.083, 1, 2, 2, 4, 6 and 12 H, respectively, after tail administration of dimethophrine-7-3H.
View Article and Find Full Text PDFGas chromatographic determination of dimethophrine in biological specimens of rabbit.
Arzneimittelforschung
April 1977
A method to measure the alpha-sympathomimetic amine, 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-monomethyl-amino-ethanol (dimethophrine, DMP), was developed and applied for the determination of the drug in biological specimens. The gas chromatographic degradation of the drug was investigated, and in order to avoid this process, DMP is converted to the trifluoroacetyl derivative and assayed by gas liquid chromatography on an OV 1' column. The minimum detectable amount is 25 pg per injection.
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