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Effect of exercise training on modulating the TH17/TREG imbalance in individuals with severe COPD: A randomized controlled trial.
Pulmonology
December 2025
Laboratory of Experimental Therapeutics, LIM-20, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Background: Chronic obstructive pulmonary disease (COPD) induces an imbalance in T helper (Th) 17/regulatory T (Treg) cells that contributes to of the dysregulation of inflammation. Exercise training can modulate the immune response in healthy subjects.
Objective: We aimed to evaluate the effects of exercise training on Th17/Treg responses and the differentiation of Treg phenotypes in individuals with COPD.
Residual Effects of Physical Exercise After Periods of Training Cessation in Older Adults: A Systematic Review With Meta-Analysis and Meta-Regression.
Scand J Med Sci Sports
January 2025
Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Melilla, Spain.
We aimed to determine the persisting effects of various exercise modalities and intensities on functional capacity after periods of training cessation in older adults. A comprehensive search was conducted across the Cochrane Library, PubMed/MEDLINE, Scopus, and Web of Science Core Collection up to March 2024 for randomized controlled trials examining residual effects of physical exercise on functional capacity in older adults ≥ 60 years. The analysis encompassed 15 studies and 21 intervention arms, involving 787 participants.
View Article and Find Full Text PDFEffect of Defined Block Sequence Terpolymers on Antifungal Activity and Biocompatibility.
Macromol Biosci
January 2025
Cluster for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, UNSW, Sydney, NSW, 2052, Australia.
Invasive fungal infections cause over 3.7 million deaths worldwide annually, underscoring the critical need for new antifungal agents. Developing selective antifungal agents is challenging due to the shared eukaryotic nature of both fungal and mammalian cells.
View Article and Find Full Text PDFA Soft Robotic Sleeve for Physiotherapy: Improving Elbow Rehabilitation in Baseball Pitchers.
Physiother Res Int
January 2025
Department of Biomedical Engineering, University of Engineering and Technology (UET) Lahore, Narowal Campus, Narowal, Pakistan.
Background And Purpose: Throwing a baseball involves intense exposure of the arm to high speeds and powerful forces, which contributes to an increasing prevalence of arm injuries among athletes. Traditional rigid exoskeletons and rehabilitation equipment frequently lack portability, safety, ergonomic design, and affordability. Traditional rehabilitation approaches frequently require therapist monitoring, resulting in therapy delays.
View Article and Find Full Text PDFSurgical treatment of congenital pseudarthrosis of the Tibia in children: CPAM-LRC consensus and guidelines.
Int J Surg
January 2025
Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: Congenital pseudarthrosis of the tibia (CPT) is a rare condition typically manifesting within the first decade of life. The primary objectives of surgical intervention for CPT include achieving long-term bony union of the tibia, preventing or minimizing limb length discrepancies (LLD), avoiding mechanical axis deviations of the tibia and adjacent joints, and preventing refracture. This study aims to conduct a systematic review of current treatment methods for CPT to determine the most effective non-surgical and surgical management strategies for pediatric patients with this condition.
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