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Vitamin D as an add-on therapy to phosphodiesterase-5 inhibitor in experimental pulmonary arterial hypertension.
Am J Physiol Lung Cell Mol Physiol
January 2025
Department of Pharmacology and Toxicology. School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Severe vitamin D (vitD) deficiency is a very common condition in patients with pulmonary arterial hypertension (PAH) and it is predictor of poor prognosis. There is emerging evidence suggesting a connection between the insufficient response to phosphodiesterase-5 inhibitors (PDE5i) and vitD deficiency in patients with PAH. In the present translational study, vitD deficiency was induced in Wistar rats by exposure to vitD free diet for 5 weeks and followed by Su5416 administration and hypoxia (10%) for 3 weeks, a standard experimental model of PAH.
View Article and Find Full Text PDFIgA vasculitis with nephritis accompanied by pulmonary tuberculosis: a case report.
CEN Case Rep
January 2025
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
A 69-year-old Japanese man developed abdominal pain, purpura, proteinuria, and hematuria while receiving treatment for pulmonary tuberculosis. A skin biopsy revealed IgA-positive leukocytoclastic vasculitis, and a renal biopsy showed IgA-positive mesangial proliferative glomerulonephritis with crescent formation. Based on these findings, we diagnosed IgA vasculitis with nephritis (IgAVN) and initiated treatment.
View Article and Find Full Text PDFBackground: Timely identification of mild cognitive impairment (MCI) is key to early intervention. While primary care providers are the most likely entry point to detect early signs of MCI, their detection rates are low. Building upon a published study, we used electronic health records (EHR) to develop a clinically enhanced MCI risk prediction algorithm.
View Article and Find Full Text PDFBackground: The increasing incidence of cognitive impairment in older adults poses significant, complex challenges for patients and their families. While specialists have traditionally addressed this care, there is an urgent need to shift diagnosis and management of mild cognitive impairment (MCI) and dementia to primary care. The annual wellness visit for Medicare recipients provides an excellent opportunity for primary care providers (PCPs) to assess patients who may need a cognitive evaluation.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Background: To provide a nationally representative estimate of the burden of multiple comorbidities (MCM) among community-dwelling Medicare beneficiaries with Alzheimer's disease (AD) and AD related dementias (ADRD).
Method: We analyzed national sampling data in Medicare beneficiaries aged ≥65 (n = 34,318) from the 2018-2020 Medicare Current Beneficiaries Surveys. AD/ADRD and twelve chronic comorbidities (hypercholesterolemia, hypertension, diabetes, coronary heart disease, heart failure, stroke, depression, mental disorder, chronic kidney disease, chronic obstructive pulmonary disease, arthritis, and osteoporosis) were examined.
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