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Reference-Based Standardization Approach Stabilizing Small Batch Risk Prediction via Polygenic Score.
Genet Epidemiol
March 2025
Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan.
The polygenic score (PGS) holds promise for motivating preventive behavioral changes. However, no clinically validated standardization methodology currently exists. Here, we demonstrate the efficacy of a "reference-based" approach for standardization.
View Article and Find Full Text PDFWillingness to pay for the effect of SARS-CoV-2 antivirals in preventing COVID-19 transmission to others in the Japanese population.
J Med Econ
January 2025
Milliman Inc, Tokyo, Japan.
Objective: This study aimed to investigate the willingness to pay (WTP) of the Japanese population for the transmission prevention function of SARS-CoV-2 antiviral treatments and identify the attributes associated with higher WTP.
Methods: A web-based survey (registration number: UMIN000054955) was conducted from May 17 to June 1, 2024, targeting a general population using a survey company panel. We aimed to obtain around 3,000 valid responses.
Performance and validation of a digital memory test across the Alzheimer's disease continuum.
Brain Commun
January 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Digital cognitive testing using online platforms has emerged as a potentially transformative tool in clinical neuroscience. In theory, it could provide a powerful means of screening for and tracking cognitive performance in people at risk of developing conditions such as Alzheimer's disease. Here we investigate whether digital metrics derived from an in-person administered, tablet-based short-term memory task-the 'What was where?' Oxford Memory Task-were able to clinically stratify patients at different points within the Alzheimer's disease continuum and to track disease progression over time.
View Article and Find Full Text PDFExamining the associations between social support and postpartum depression symptoms among adolescent mothers in Nairobi, Kenya.
Reprod Health
January 2025
Sexual, Reproductive, Maternal, Newborn, Child and Adolescent Health (SRMNCAH) Unit, African Population and Health Research Center, Nairobi, Kenya.
Background: Globally, adolescent mothers are at increased risk for postpartum depression (PPD). In Kenya, 15% of adolescent girls become mothers before the age of 18. While social support can buffer a mother's risk of PPD, there are gaps in knowledge as to whether-and which types-of social support are protective for adolescent mothers in Kenya.
View Article and Find Full Text PDFDigital twin driven electrode optimization for wearable bladder monitoring via bioimpedance.
NPJ Digit Med
January 2025
School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Monitoring fluid intake and output for congestive heart failure (CHF) patients is an essential tool to prevent fluid overload, a principal cause of hospital admissions. Addressing this, bladder volume measurement systems utilizing bioimpedance and electrical impedance tomography have been proposed, with limited exploration of continuous monitoring within a wearable design. Advancing this format, we developed a conductivity digital twin from radiological data, where we performed exhaustive simulations to optimize electrode sensitivity on an individual basis.
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