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sp. nov., isolated from the intestines of .
Int J Syst Evol Microbiol
January 2025
College of Life Science, Shenyang Normal University, Shenyang 110000, PR China.
A Gram-stain-negative, aerobic, motile, catalase-positive, oxidase-positive, short rod-shaped marine bacterium, designated as YIC-827, was isolated from Qingdao, Shandong Province, China. The results showed that cells of strain YIC-827 could grow optimally at 25-35 °C, pH 6.5-7.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of São Paulo Medical School, São Paulo, São Paulo, Brazil.
Background: Emerging preclinical studies show that cannabidiol (CBD) has neuroprotective and anti-inflammatory effects that may have the potential to improve Alzheimer's disease (AD) therapy. Although much progress has been made in understanding the pathology of AD, its multifactorial nature can't be mimicked in a single preclinical model. In order to improve preclinical results and search for AD better interventions, the aim of this study is to compare the effects of CBD in two AD animal models in a sex-dependent manner.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Background: Cytoplasmic inclusions of TDP-43 are the primary pathology in the majority of ALS and FTLD cases. Recent reports in cell and animal models suggest TDP-43 pathology may enhance neuronal excitability, which could contribute to neurodegeneration via excitotoxicity. Dox-regulatable rNLS8 mice express human TDP-43 with mutations in the nuclear localization signal (hTDP-43NLSm) to promote cytoplasmic accumulation.
View Article and Find Full Text PDFFluorescent Heterocyclic Compound-Loaded BiSe-Polysorbate Nanoparticles for Targeted Therapy in Non-Small Cell Lung Cancer.
J Fluoresc
January 2025
Deparment of Hepatobiliary Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
This study introduces a novel approach for non-small cell lung cancer (NSCLC) treatment by developing BiSe-Polysorbate nanoparticles as a multifunctional platform for photothermal therapy and targeted drug delivery. The BiSe-Polysorbates nanoparticles are engineered as innovative photosensitive drug carriers, enhancing biocompatibility through the combination of BiSe and Polysorbates. Characterization techniques such as Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ultraviolet-visible (UV-Vis) spectroscopy confirm the successful synthesis of the nanoparticles.
View Article and Find Full Text PDFOlive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights.
Inflammopharmacology
January 2025
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, 45210, Pakistan.
Flurbiprofen (FBP) is poorly water-soluble BCS class II drug with anti-inflammatory and analgesic effects, used to treat arthritis and degenerative joint diseases. This study was aimed to develop SNEDDS loaded with FBP. Six SNEDDS using two oils olive oil (F, F, F) and castor oil (F, F, F) with three different Smix ratios consisting of Tween 20 and PEG 400 (1:1, 1:2, 2:1) were prepared and characterized.
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