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Proximity proteomics provides a new resource for exploring the function of Afadin and the complexity of cell-cell adherens junctions.
Biol Open
February 2025
Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
The network of proteins at the interface between cell-cell adherens junctions and the actomyosin cytoskeleton provides robust yet dynamic connections that facilitate cell shape change and motility. While this was initially thought to be a simple linear connection via classic cadherins and their associated catenins, we now have come to appreciate that many more proteins are involved, providing robustness and mechanosensitivity. Defining the full set of proteins in this network remains a key objective in our field.
View Article and Find Full Text PDFHemoadhican Fiber Composite with Carbon Dots for Treating Severe Hemorrhage and Infected Wounds.
ACS Appl Mater Interfaces
January 2025
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, Jiangsu 210094, China.
Uncontrolled bleeding and infection following trauma continue to pose significant clinical challenges. This study employs hemoadhican (HD) polysaccharide, known for its superior hemostatic properties, as the foundational material to synthesize antibacterial carbon dots (H-CDs) through a hydrothermal method at various temperatures. The H-CDs exhibiting optimal antimicrobial properties were identified via in vitro antimicrobial characterization.
View Article and Find Full Text PDFMetabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes- results from the CEV-65 randomized trial.
Heliyon
January 2025
Department of Nursing, School of Health Sciences, Ariel University, Ariel, Israel.
Aims: This study evaluated the effects of circuit resistance training (CRT), a vegetarian/Mediterranean diet (VegMedD), and empagliflozin on Resting Metabolic Rate (RMR) in older adults with Type 2 Diabetes (T2DM).
Methods: 67 participants from CEV-65 trial (≥65 years, 61 % female) were randomly assigned to CRT, VegMedD, or empagliflozin for 10 weeks. Assessments included RMR, medical, metabolic, nutritional, anthropometric and functional measurements.
Deciphering the Dynamic Interplay between Rhizobacteria and Root Exudates via Cerium Oxide Nanomaterials Modulation for Promoting Soybean Yield and Quality.
J Agric Food Chem
January 2025
Institute of Environmental Processes and Pollution Control, and School of Environment and Ecology, Jiangnan University, Wuxi 214122, China.
The interplay between root exudates and rhizobacteria is essential for enhancing agricultural productivity. Herein, the impacts of cerium dioxide nanomaterials (CeO NMs) on these interactions in soybean plants were investigated. Following 3-5 weeks of exposure to 5 mg·kg CeO NMs, the composition of root exudates changed over time, with isoflavone levels increasing by 6.
View Article and Find Full Text PDFIs lean mass quantity or quality the determinant of maximal fat oxidation capacity? The potential mediating role of cardiorespiratory fitness.
J Int Soc Sports Nutr
December 2025
University of Cadiz, ExPhy Research Group, Department of Physical Education, Puerto Real, Spain.
Background: Impaired fat oxidation is linked to cardiometabolic risk. Maximal fat oxidation rate (MFO) reflects metabolic flexibility and is influenced by lean mass, muscle strength, muscle quality - defined as the ratio of strength to mass - and cardiorespiratory fitness. The relationship between these factors and fat oxidation is not fully understood.
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