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Cellular Senescence Genes as Cutting-Edge Signatures for Abdominal Aortic Aneurysm Diagnosis: Potential for Innovative Therapeutic Interventions.
J Cell Mol Med
January 2025
State Key Laboratory of Frigid Zone Cardiovascular Diseases, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
Abdominal aortic aneurysm (AAA) is the most prevalent dilated arterial aneurysm that poses a significant threat to older adults, but the molecular mechanisms linking senescence to AAA progression remain poorly understood. This study aims to identify cellular senescence-related genes (SRGs) implicated in AAA development and assess their potential as therapeutic targets. Four hundred and twenty-nine differentially expressed genes (DEGs) were identified from the GSE57691 training set, and 867 SRGs were obtained.
View Article and Find Full Text PDFClinical Presentation and Percutaneous Treatment of Hemolytic Anemia Associated With Paravalvular Leak After TAVR.
JACC Case Rep
January 2025
Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Paravalvular leak (PVL) following transcatheter aortic valve replacement (TAVR) is an established complication, albeit rarely associated with hemolytic anemia. This report details 3 cases of significant hemolytic anemia attributed to TAVR-induced PVL, each with distinct clinical presentations and manifestations. These cases underscore the diverse and occasionally subtle clinical presentation of aortic PVL-associated hemolytic anemia.
View Article and Find Full Text PDFLeft Main Coronary Artery Ostial Stenosis Caused by Syphilitic Aortitis Presenting With Syncope.
JACC Case Rep
January 2025
Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
A 51-year-old man with a history of antibiotic therapy for syphilis 1 month ago presented with syncope. Computed tomography revealed circumferential aortic wall thickening complicating severe stenosis of left main coronary ostium. Abnormalities in serologic and cerebrospinal fluid tests led to the diagnosis of syphilitic aortitis and neurosyphilis.
View Article and Find Full Text PDFSurgical Resected Cardiac Angiosarcoma in a 75-Year-Old Patient With a Mitral Valve Bioprosthesis.
JACC Case Rep
December 2024
Department of Nuclear Medicine, Hospital Clínico San Carlos, Madrid, Spain.
A 75-year-old patient with a history of mitral and aortic valve replacement surgery 7 years ago, presented with progressive dyspnea. Transesophageal echocardiogram showed a mass suggestive of bioprosthetic mitral valve thrombosis. We present the investigation process using imaging, surgical findings, nuclear medicine, and histopathology that result in the diagnosis of cardiac angiosarcoma.
View Article and Find Full Text PDFLeft atrial reservoir strain as a predictor of cardiac dysfunction in a murine model of pressure overload.
Acta Physiol (Oxf)
February 2025
PhyMedExp, IPAM/Biocampus, University of Montpellier, INSERM, CNRS., Montpellier, France.
Aim: Left atrial (LA) strain is emerging as a valuable metric for evaluating cardiac function, particularly under pathological conditions such as pressure overload. This preclinical study investigates the predictive utility of LA strain on cardiac function in a murine model subjected to pressure overload, mimicking pathologies such as hypertension and aortic stenosis.
Methods: High-resolution ultrasound was performed in a cohort of mice (n = 16) to evaluate left atrial and left ventricular function at baseline and 2 and 4 weeks after transverse aortic constriction (TAC).
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