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Dissemination of clinical harboring the gene in Pakistan.
Front Microbiol
January 2025
Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan.
Background: Colistin is an antibiotic used as a last resort to treat multidrug-resistant Gram-negative bacterial infections. Plasmid-mediated mobile colistin-resistant () genes in () are disseminated globally and are considered to be a major public health threat. This study aimed to determine the molecular characteristics of colistin-resistant isolates in clinical settings in Pakistan.
View Article and Find Full Text PDFAntimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics.
PLoS One
January 2025
National Marine Science Centre, Southern Cross University, Coffs Harbour, NSW, Australia.
Discovering new antibiotics and increasing the efficacy of existing antibiotics are priorities to address antimicrobial resistance. Antimicrobial proteins and peptides (AMPPs) are considered among the most promising antibiotic alternatives and complementary therapies. Here, we build upon previous work investigating the antibacterial activity of a semi-purified hemolymph protein extract (HPE) of the Australian oyster Saccostrea glomerata.
View Article and Find Full Text PDFSpatial distribution patterns, hotspots of contaminants of emerging concern and driving factors in a river network of Xizang Plateau.
Environ Res
January 2025
CAS Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China. Electronic address:
This study encompasses the explication of systematic spatial distribution patterns and identification of hotspots of contaminants of emerging concern (CECs) across the network of rivers, including Yarlung Tsangpo River and its tributaries in Xizang Plateau. A total of 16 CECs were detected in wide range of frequencies and concentrations ranging from below limit of detection (BLD) - 163.13 ng/L across the river network, indicating widespread spatial heterogeneity.
View Article and Find Full Text PDFPharmaceutical residues and caffeine in Arctic fjord waters (west Spitsbergen).
Mar Pollut Bull
January 2025
Institute of Oceanology of the Polish Academy of Sciences, Powstańców Warszawy 55, 81-712 Sopot, Poland. Electronic address:
This study examines pharmaceutical residues in the seawater of west Spitsbergen fjords, using indicator compounds that represent different types of medications with various therapeutic uses (sulfamethoxazole, trimethoprim, carbamazepine, diclofenac, and caffeine). Over three years (summer 2018-2021), trimethoprim, carbamazepine, diclofenac, and caffeine were detected in the investigated fjords (Hornsund, Adventfjorden, Grønnfjorden, Isfjorden, and Kongsfjorden), with diclofenac and caffeine being the most common. Sulfamethoxazole was below the limit of detection in all samples.
View Article and Find Full Text PDFAssessment of bacteriological and immunological markers in urinary tract infection and the effect of antibiotics on the isolated bacteria.
Cell Mol Biol (Noisy-le-grand)
January 2025
Laboratory of Plant Improvement and Valorization of Agro-resources, National School of Engineers of Sfax, University of Sfax, Sfax LR.16ES20, Tunisia.
Urinary tract infections (UTIs) are recognized as the second most common medical condition, following respiratory infections. Despite the availability of numerous efficacious antibiotics for the management of UTIs, the rising incidence of bacterial resistance presents significant challenges in the treatment of these infections. Bacteria are endowed with the ability to reproduce and develop resistance mechanisms against antibiotics.
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