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Discrete event simulation model of an acute stroke treatment process at a comprehensive stroke center: Determining the ideal improvement strategies for reducing treatment times.
J Neurol Sci
January 2025
Department of Industrial Engineering, Faculty of Engineering, Dalhousie University, Halifax, Canada; Division of Neurology, Department of Medicine, Dalhousie University, Halifax, Canada; Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, Canada.
Background: Fast treatment is crucial for ischemic stroke patients; the probability of good patient outcomes increases with faster treatment. Treatment times can be improved by making changes to the treatment process. However, it is challenging to identify the benefits of changes prior to implementation.
View Article and Find Full Text PDFCatheter-directed interventions in acute pulmonary embolism. Position statement of SEC-Interventional Cardiology Association/SEC-Ischemic Heart Disease and Acute Cardiovascular Care Association/SEC-Working Group on Pulmonary Hypertension.
Rev Esp Cardiol (Engl Ed)
November 2024
Servicio de Cardiología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Article Synopsis
- Pulmonary embolism (PE) is a major cause of hospital deaths and cardiovascular issues, with traditional treatments like anticoagulation and surgery being standard options.
- Recent advancements include catheter-directed interventions (CDI), such as thrombolysis, which may quickly enhance patient outcomes, despite limited supporting evidence from clinical trials.
- A joint report highlights the need for rapid response teams, thorough patient evaluation, and collaborative methods to optimize treatment and outcomes for those dealing with PE.
Bidirectional Elastic PTFE Small Diameter Artificial Blood Vessel Grafts and Surface Antithrombotic Functionalized Construction.
ACS Appl Bio Mater
October 2024
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, China.
Expanded polytetrafluoroethylene (ePTFE) failed to achieve clinical application in the field of small-diameter blood vessels due to its lack of elasticity in the circumferential direction and high stiffness. Excellent multidirectional elasticity and dynamic compliance matching with natural blood vessels are important means to solve the problem of acute thrombosis and poor long-term patency. Herein, novel PTFE spinning blood vessels were prepared by the PTFE emulsion electrospinning process, which not only presented good bidirectional elasticity but also promoted the adhesion and proliferation of endothelial cells and induced the contractile expression of SMCs.
View Article and Find Full Text PDFGuidelines on deep vein thrombosis of the Brazilian Society of Angiology and Vascular Surgery.
J Vasc Bras
September 2024
Sociedade Brasileira de Angiologia e de Cirurgia Vascular - SBACV-SP, São Paulo, SP, Brasil.
Deep vein thrombosis is one of the main causes of inpatient and outpatient morbidity, both in medical and surgical patients, significantly impacting mortality statistics and requiring prompt diagnosis so that treatment can be initiated immediately. This document was prepared and reviewed by 11 specialists certified by the Brazilian Society of Angiology and Vascular Surgery, who searched the main databases for the best evidence on the diagnostic (physical examination, imaging) and therapeutic approaches (heparin, coumarins, direct oral anticoagulants, fibrinolytics) to the disease.
View Article and Find Full Text PDFEnhanced-permeability delivery system for hydroxyl radical-responsive NIR-II fluorescence-monitored thrombolytic therapy.
Colloids Surf B Biointerfaces
January 2025
The Radiology Department of Shanxi Provincial Peoples Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan 030001, China. Electronic address:
Article Synopsis
- Pathological thrombus can lead to severe health issues like heart attacks and strokes, complicating effective treatment and monitoring.
- Researchers developed a multifunctional nanoplatform (TG-OPDEA@UK/MnO-H1080) to enhance thrombus penetration and enable real-time monitoring through advanced fluorescence imaging.
- The nanoparticles, designed to carry a thrombolytic agent and a fluorescent marker, displayed a significant increase in therapeutic effectiveness while minimizing bleeding risks in a mouse model.
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